帕金森病脑萎缩的特征。一项CT扫描研究。

Features of brain atrophy in Parkinson's disease. A CT scan study.

作者信息

Steiner I, Gomori J M, Melamed E

出版信息

Neuroradiology. 1985;27(2):158-60. doi: 10.1007/BF00343788.

Abstract

Multiple parameters for brain volume and mass were studied in 85 parkinsonian patients and in 149 normal controls aged 24 to 84 using CT scanning. In controls there was reduction in brain substance with advancing age. Increased brain atrophy in patients with Parkinson's disease (PD) was mainly observed in the younger age group of 24 to 49. This included parameters evaluating the size of the lateral and third ventricles (P less than 0.05 and P less than 0.01 respectively) and the size of the subarachnoid space in the frontal interhemispheric and Sylvian fissures (P less than 0.005 and P less than 0.01). With computed canonical correlation analysis a formula was obtained which expressed the tendency of the atrophic process in PD to involve the areas surrounding the third ventricle and the mesial aspect of the frontal lobes more than during normal aging.

摘要

利用CT扫描对85例帕金森病患者和149名年龄在24至84岁的正常对照者的多个脑容量和脑质量参数进行了研究。在对照组中，脑实质随着年龄的增长而减少。帕金森病（PD）患者脑萎缩增加主要见于24至49岁的较年轻年龄组。这包括评估侧脑室和第三脑室大小的参数（分别为P<0.05和P<0.01）以及额叶半球间和大脑外侧裂蛛网膜下腔的大小（P<0.005和P<0.01）。通过计算典型相关分析得出一个公式，该公式表明与正常衰老过程相比，PD萎缩过程更倾向于累及第三脑室周围区域和额叶内侧。