Marttila R J, Rinne U K
Acta Neurol Scand. 1976 Nov;54(5):431-41. doi: 10.1111/j.1600-0404.1976.tb04375.x.
The occurrence of dementia in patients with Parkinson's disease was studied in a Parkinsonian population consisting of all traceable patients residing in a defined area. The prevalence of dementia was found to be 29 per cent in 444 patients studied. The frequency of dementia increased with advancing age and the patients showing signs of clinical arteriosclerosis were more often demented than the patients without arteriosclerosis. There was, however, an evident association between the stage of the disease and the frequency of dementia. The most severely disabled patients displayed dementia more often than the mildly affected, both among the patients with and without arteriosclerosis. The demented patients showed significantly more severe rigidity and hypokinesia when compared with the non-demented. Increasing severity of rigidity and hypolinesia, in particular was found to have a positive correlation with the degree of dementia. The association between dementia and the degree of motor involvement is considered to suggest the role of subcortical structures in the patholophysiology of dementia in Parkinson's disease.
在一个由居住在特定区域内所有可追踪患者组成的帕金森病群体中，对帕金森病患者痴呆症的发生情况进行了研究。在所研究的444名患者中，痴呆症的患病率为29%。痴呆症的发病率随年龄增长而增加，有临床动脉硬化迹象的患者比没有动脉硬化的患者更常出现痴呆。然而，疾病阶段与痴呆症发病率之间存在明显关联。在有和没有动脉硬化的患者中，残疾最严重的患者比病情较轻的患者更常出现痴呆。与非痴呆患者相比，痴呆患者表现出明显更严重的僵硬和运动迟缓。尤其发现，僵硬和运动迟缓程度的增加与痴呆程度呈正相关。痴呆与运动受累程度之间的关联被认为表明了皮层下结构在帕金森病痴呆病理生理学中的作用。
