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Randomization and placebo effects in clinical trials of major depressive disorder.

作者信息

Rogers James A, Senn Stephen

机构信息

Metrum Research Group, 30 Tower Lane, Suite #140, Avon, CT, 06001-4231, USA.

Sheffield Centre for Health and Related Research (SCHARR) The University of Sheffield, Sheffield, UK.

出版信息

Transl Psychiatry. 2025 Feb 5;15(1):43. doi: 10.1038/s41398-025-03263-0.

DOI:10.1038/s41398-025-03263-0
PMID:39910057
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11799522/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/11799522/7710b12423e2/41398_2025_3263_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/11799522/7710b12423e2/41398_2025_3263_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/11799522/7710b12423e2/41398_2025_3263_Fig1_HTML.jpg

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本文引用的文献

1
Interpreting clinical trial outcomes complicated by placebo response with an assessment of false-negative and true-negative clinical trials in depression using propensity-weighting.使用倾向评分加权法评估抑郁障碍中假阴性和真阴性临床试验，以解释受安慰剂反应影响的临床试验结果。
Transl Psychiatry. 2023 Dec 14;13(1):388. doi: 10.1038/s41398-023-02685-y.
2
Is High Placebo Response Really a Problem in Depression Trials? A Critical Re-analysis of Depression Studies.高安慰剂反应在抑郁症试验中真的是个问题吗？对抑郁症研究的批判性重新分析。
Innov Clin Neurosci. 2019 Jul 1;16(7-08):12-17. eCollection 2019 Jul-Aug.
3
A brief note regarding randomization.
关于随机化的简短说明。
Perspect Biol Med. 2013 Summer;56(3):452-3. doi: 10.1353/pbm.2013.0024.
4
Seven myths of randomisation in clinical trials.临床试验中随机化的七大误区。
Stat Med. 2013 Apr 30;32(9):1439-50. doi: 10.1002/sim.5713. Epub 2012 Dec 17.
5
Importance of trends in the interpretation of an overall odds ratio in the meta-analysis of clinical trials.临床试验荟萃分析中总体比值比解释趋势的重要性。
Stat Med. 1994 Feb 15;13(3):293-6. doi: 10.1002/sim.4780130310.