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选择性激光小梁成形术治疗原发性开角型青光眼行粘小管切开联合Ologen植入术后眼压升高:一项回顾性队列研究

Selective laser trabeculoplasty for the treatment of intraocular pressure elevation after viscocanalostomy with Ologen implant in the management of primary open-angle glaucoma: a retrospective cohort study.

作者信息

Gad Ahmed Am, Abdulhalim Bahaa-Eldin Hasan, Gharib Amal F, Mohammed Amr Mahfouz

机构信息

Ophthalmology Department, Zagazig University, Zagazig, 44511, Egypt.

Ophthalmology Department, Shaqra University, Shaqra 11961, Kingdom of Saudi Arabia.

出版信息

BMC Ophthalmol. 2025 Feb 5;25(1):60. doi: 10.1186/s12886-025-03888-1.

Abstract

BACKGROUND

Selective laser trabeculoplasty (SLT) is a non-invasive treatment option for glaucoma. It uses a Q-switched Nd: YAG laser. The aim of this study was to evaluate the efficacy of SLT as a treatment option for eyes with primary open-angle glaucoma (POAG) that have previously undergone viscocanalostomy with an Ologen implant, displaying uncontrolled intraocular pressure (IOP).

METHODS

This retrospective cohort study included 26 eyes of 26 patients with POAG who had had SLT after viscocanalostomy or phacoviscocanalostomy with Ologen implant. These eyes showed a progression of glaucomatous damage, the IOP was above 21 mmHg, or with intolerable glaucoma medications. SLT was done using Tango Reflex multimodality YAG/SLT laser which is a Q-switched Nd: YAG laser producing a single 532 nm wavelength pulse with a 400 mm spot size and 3 ns pulse duration. The follow-up period was one year.

RESULTS

One year post-SLT, complete success was achieved in 19 cases (73.1%), qualified success in 4 cases (15.4%), and failure in 3 cases (11.5%). The mean decrease in IOP was 5.64 ± 4.05 mmHg, the mean reduction of antiglaucoma medications was 1.00 ± 0.85, and the mean percentage of reduction in IOP was 23.5 ± 16.4. There was a statistically significant decrease in IOP and antiglaucoma medications (p = < 0.01).

CONCLUSION

SLT is a simple and effective procedure that can be used as a treatment option for eyes with POAG after viscocanalostomy with Ologen implant to reach the target IOP and decrease the number of antiglaucoma medications.

摘要

背景

选择性激光小梁成形术(SLT)是一种用于青光眼的非侵入性治疗方法。它使用调Q Nd:YAG激光。本研究的目的是评估SLT作为一种治疗选择,用于先前已接受含Ologen植入物的粘小管成形术且眼压控制不佳的原发性开角型青光眼(POAG)患者的疗效。

方法

这项回顾性队列研究纳入了26例POAG患者的26只眼睛,这些患者在接受含Ologen植入物的粘小管成形术或晶状体粘小管成形术后接受了SLT治疗。这些眼睛显示青光眼损害进展、眼压高于21 mmHg或使用了难以耐受的青光眼药物。使用Tango Reflex多模态YAG/SLT激光进行SLT,这是一种调Q Nd:YAG激光,产生单个532 nm波长脉冲,光斑尺寸为400 mm,脉冲持续时间为3 ns。随访期为一年。

结果

SLT术后一年,19例(73.1%)获得完全成功,4例(15.4%)获得合格成功,3例(11.5%)失败。眼压平均降低5.64±4.05 mmHg,抗青光眼药物平均减少1.00±0.85,眼压平均降低百分比为23.5±16.4。眼压和抗青光眼药物有统计学显著降低(p = <0.01)。

结论

SLT是一种简单有效的手术方法,可作为含Ologen植入物的粘小管成形术后POAG患者的治疗选择,以达到目标眼压并减少抗青光眼药物的使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e08/11800543/5ca4aa9d7fe4/12886_2025_3888_Fig1_HTML.jpg

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