Chase R A, Pearson S, Nunn P B, Lantos P L
Neurosci Lett. 1985 Mar 22;55(1):89-94. doi: 10.1016/0304-3940(85)90317-9.
alpha- and beta-N-oxalyl-L-alpha, beta-diaminopropionic acids, isolated from Lathyrus sativus seed, which is implicated in the pathogenesis of human neurolathyrism, were injected into rat lumbar cerebrospinal fluid. The alpha-isomer was neither acutely nor chronically toxic, whereas the beta-isomer was both an acute and a chronic neurotoxin in this test system. These results are relevant to the aetiology of neurolathyrism and suggest that the conversion of the beta- to the alpha-isomer that occurs during boiling of the seed prior to human consumption reduces the neurotoxicity of the seed.
从与人类神经性豆状核变性发病机制有关的山黧豆种子中分离出的α-和β-N-草酰-L-α,β-二氨基丙酸被注入大鼠腰椎脑脊液中。在这个测试系统中，α-异构体既无急性毒性也无慢性毒性，而β-异构体既是急性神经毒素又是慢性神经毒素。这些结果与神经性豆状核变性的病因学相关，并表明在人类食用前种子煮沸过程中发生的β-异构体向α-异构体的转化降低了种子的神经毒性。
