Liu He, Shen Ya
Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.
Int Endod J. 2025 May;58(5):674-684. doi: 10.1111/iej.14208. Epub 2025 Feb 6.
Stimuli-responsive hydrogels are smart and functional materials that respond to various environmental stimuli, including temperature, light, magnetic field, pH, redox, enzymes and glucose. This responsiveness allows for the controlled release of therapeutic agents encapsulated within the hydrogels, enhancing treatment precision, improving therapeutic outcomes and minimizing side effects. Such hydrogels show great potential in root canal disinfection, management of dental pulp inflammation and pulp regeneration, making them promising candidates for more personalized and effective endodontic treatments. This article provides an overview of the latest advancements in the design and application of stimuli-responsive hydrogels in endodontics, emphasizing their potential to revolutionize endodontic treatments. It also addresses current challenges and explores future directions in the field, aiming to inspire and motivate researchers to further engage in or intensify their efforts within this promising area of research.
刺激响应性水凝胶是智能且功能性的材料，可对各种环境刺激做出响应，包括温度、光、磁场、pH值、氧化还原、酶和葡萄糖。这种响应性使得封装在水凝胶中的治疗剂能够实现可控释放，提高治疗精度、改善治疗效果并将副作用降至最低。此类水凝胶在根管消毒、牙髓炎症管理和牙髓再生方面显示出巨大潜力，使其成为更个性化、更有效的牙髓治疗的有前景候选材料。本文概述了刺激响应性水凝胶在牙髓病学设计与应用方面的最新进展，强调了它们革新牙髓治疗的潜力。它还讨论了当前的挑战，并探索了该领域的未来方向，旨在激励研究人员在这一有前景的研究领域进一步参与或加大努力。
