Huebers H, Csiba E, Huebers E, Finch C A
Proc Soc Exp Biol Med. 1985 Jun;179(2):222-6. doi: 10.3181/00379727-179-42090.
The delivery of transferrin iron from four animal species and man to homologous reticulocytes was measured at different transferrin saturations. Total iron uptake in the in vitro reticulocyte incubation model employed followed a hyperbolic curve, increasing as the transferrin saturation increased but at a progressively slower rate. In all species, there was a much greater iron delivery from diferric as compared to monoferric transferrin, the molecular advantage varying from 8:1 to 14:1. The majority of iron was delivered from diferric transferrin when transferrin saturations exceeded 13-19% depending on the species. Thus a general similarity exists in the transferrin-iron interactions in these mammalian species. Formuli have been provided whereby the iron utilization curve may be calculated when uptake has been determined at any one transferrin saturation.
在不同的转铁蛋白饱和度下，测定了来自四种动物物种和人类的转铁蛋白铁向同源网织红细胞的传递。在所采用的体外网织红细胞孵育模型中，总铁摄取遵循双曲线曲线，随着转铁蛋白饱和度的增加而增加，但速率逐渐减慢。在所有物种中，与单铁转铁蛋白相比，双铁转铁蛋白的铁传递要多得多，分子优势从8:1到14:1不等。当转铁蛋白饱和度超过13%-19%（取决于物种）时，大部分铁由双铁转铁蛋白传递。因此，这些哺乳动物物种在转铁蛋白-铁相互作用方面存在普遍的相似性。已经提供了公式，据此当在任何一种转铁蛋白饱和度下测定摄取量时，可以计算铁利用曲线。
