Department of Chemistry, Faculty of Science, University of Cape Town, Rondebosch, Cape Town 7700, South Africa.
Molecules. 2020 Nov 12;25(22):5276. doi: 10.3390/molecules25225276.
In the face of the recent pandemic and emergence of infectious diseases of viral origin, research on parasitic diseases such as malaria continues to remain critical and innovative methods are required to target the rising widespread resistance that renders conventional therapies unusable. The prolific use of auxiliary metallo-fragments has augmented the search for novel drug regimens in an attempt to combat rising resistance. The development of organometallic compounds (those containing metal-carbon bonds) as antimalarial drugs has been exemplified by the clinical development of ferroquine in the nascent field of Bioorganometallic Chemistry. With their inherent physicochemical properties, organometallic complexes can modulate the discipline of chemical biology by proffering different modes of action and targeting various enzymes. With the beneficiation of platinum group metals (PGMs) in mind, this review aims to describe recent studies on the antimalarial activity of PGM-based organometallic complexes. This review does not provide an exhaustive coverage of the literature but focusses on recent advances of bioorganometallic antimalarial drug leads, including a brief mention of recent trends comprising interactions with biomolecules such as heme and intracellular catalysis. This resource can be used in parallel with complementary reviews on metal-based complexes tested against malaria.
面对最近的大流行病和病毒性传染病的出现，疟疾等寄生虫病的研究仍然至关重要，需要创新方法来应对日益普遍的耐药性，使传统疗法无法使用。辅助金属片段的大量使用增加了寻找新的药物治疗方案的努力，以对抗不断上升的耐药性。铁喹啉在生物有机金属化学这一新兴领域的临床开发就是将金属有机化合物（含有金属-碳键的化合物）作为抗疟药物开发的一个例子。由于其固有的物理化学性质，金属有机配合物可以通过提供不同的作用模式和针对各种酶来调节化学生物学领域。考虑到铂族金属（PGM）的富集，本综述旨在描述基于 PGM 的金属有机配合物的抗疟活性的最新研究。本综述没有对文献进行详尽的综述，但重点介绍了生物有机金属抗疟药物先导物的最新进展，包括简要提及最近的趋势，包括与血红素和细胞内催化等生物分子的相互作用。本资源可与针对疟疾进行测试的基于金属的配合物的互补综述并行使用。
