Association of the dopamine D2 receptor gene SNP rs1800497 with postoperative nausea and vomiting: A prospective cohort study.

BACKGROUND

Postoperative nausea and vomiting (PONV) are the most frequent complications in the context of anaesthesia. Several studies suggest a contribution of genetic traits to PONV disposition. Single nucleotide polymorphisms (SNPs) located in the cholinergic receptor muscarinic 3 gene (rs2165870) and the potassium voltage-gated channel subfamily B member 2 (rs349358) have been described as independent risk factors for the occurrence of PONV. In addition, further SNPs might be associated with an increased PONV risk, for example a dopamine D2 receptor () SNP (rs1800497).

OBJECTIVE

The primary aim of our study was the development of a new PONV prediction score which includes genetic information of SNPs in the genes and which have been already associated with PONV. The secondary aim of our study was to investigate the association of five additional SNPs with PONV.

DESIGN

Prospective cohort study.

SETTING

Single centre study in Germany.

RESULTS

We could not establish a new PONV prediction score that includes genetic information, due to limited association of the SNP and SNP with PONV. Interestingly, the GA and AA genotypes of the rs1800497 in the dopamine D2 receptor gene were associated with PONV 24 h postoperatively, with a relative risk (RR) of GA/AA genotype vs. GG genotype of 1.5 [95% confidence interval (CI) 1.06 to 2.01,  = 0.02]. This association was independent from the Apfel score in a multivariate logistic regression analysis (RR 1.4, 95% CI 1.03 to 1.90,  = 0.03).

CONCLUSION

The construction of a new PONV prediction score including genetic information was not possible due to limited association of the and SNPs. However, the GA and AA genotypes (rs1800497) were associated with PONV and this SNP might be a future candidate for further validation studies aiming for molecular-derived PONV prediction models.

TRIAL REGISTRATION

German Clinical Study Register - DRKS00021051.