Sv Sowmya, Augustine Dominic, Hosmani Jagdish, Pagnoni Francesco, Reda Rodolfo, Testarelli Luca, Patil Shankargouda
Department of Oral & Maxillofacial Pathology and Oral Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru, India.
Department of Diagnostic Dental Sciences, Oral Pathology Section, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Front Dent Med. 2024 Nov 21;5:1482166. doi: 10.3389/fdmed.2024.1482166. eCollection 2024.
Nanoparticles have orchestrated a paradigm shift in the landscape of cancer diagnosis and therapy, presenting a multifaceted approach to tackle the intricacies of malignancies. This comprehensive exposition delves deep into the forefront of nanomedicine, elucidating pivotal strategies and innovations primed to metamorphose the domain of cancer management.
Nanoparticles transcend traditional boundaries, enabling meticulous, site-specific drug release while minimizing systemic toxicity. Intricately designed activation mechanisms, encompassing pH and enzymatic responsivity, along with concentration-dependent strategies, exploit the distinctive attributes of cancer cells, heralding an era characterized by unprecedented therapeutic precision. The pervasive influence of nanotechnology extends to diagnostics, unlocking the realm of early disease detection and personalized treatment. These versatile agents bestow empowering capabilities upon sensitive imaging modalities, affording real-time monitoring and theranostic potential.
This exposition showcases the evolution of cutting-edge nanoplatforms, bridging the chasm between diagnosis and therapy, thereby redefining the confines of cancer care. This review elucidates strategies to combat drug resistance, a perennial challenge within cancer management. By targeting efflux transporters, modulating apoptotic pathways, and countering hypoxia-induced resistance, nanoparticles stand at the vanguard of therapeutic innovation, poised to reinvigorate treatment efficacy.
DISCUSSION & CONCLUSION: Moreover, this exposé underscores the imminent clinical translation of nanoparticle-based drugs, accentuating their potential to metamorphose the landscape of cancer management. Liposomal vaccines, nano-pharmaceuticals, and nanochemodrugs, currently navigating the crucible of clinical trials, bear immense promise in advancing the realm of precision medicine. In this epoch of precision medicine, nanoparticle-fueled innovations stand poised to propel cancer diagnosis and therapy to unprecedented peaks.
纳米颗粒在癌症诊断和治疗领域引发了一场范式转变，为应对恶性肿瘤的复杂性提供了多方面的方法。本全面阐述深入探究了纳米医学的前沿领域，阐明了旨在改变癌症管理领域的关键策略和创新。
纳米颗粒突破了传统界限，能够实现精确的、针对特定部位的药物释放，同时将全身毒性降至最低。精心设计的激活机制，包括pH和酶响应性，以及浓度依赖性策略，利用癌细胞的独特属性，开创了一个前所未有的治疗精准度时代。纳米技术的广泛影响延伸到诊断领域，开启了早期疾病检测和个性化治疗的新篇章。这些多功能制剂赋予了敏感成像方式强大的功能，提供实时监测和治疗诊断潜力。
本阐述展示了前沿纳米平台的发展历程，弥合了诊断与治疗之间的差距，从而重新定义了癌症护理的范围。本综述阐明了对抗耐药性的策略，这是癌症管理中一个长期存在的挑战。通过靶向流出转运蛋白、调节凋亡途径和对抗缺氧诱导的耐药性，纳米颗粒处于治疗创新的前沿，有望重振治疗效果。
此外，本报告强调了基于纳米颗粒的药物即将进行临床转化，突出了它们改变癌症管理格局的潜力。脂质体疫苗、纳米药物和纳米化学药物目前正在临床试验的熔炉中接受检验，在推进精准医学领域方面具有巨大潜力。在这个精准医学时代，由纳米颗粒推动的创新有望将癌症诊断和治疗提升到前所未有的高度。
