Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
ACS Appl Mater Interfaces. 2022 May 11;14(18):21310-21318. doi: 10.1021/acsami.2c00941. Epub 2022 Apr 27.
A series of carbon nanomaterials, including carbon dots, carbon nanorings (CNRs), and porous carbon nanoballs, were facilely prepared by a template-free hydrothermal treatment of gluten as the sole carbon source. Driven by the hydrophobicity interaction, a concentration-dependent self-assembly of gluten was observed in an aqueous solution, leading to the subsequent formation of different morphologies of carbon nanomaterials in a hydrothermal treatment. Among these carbon nanomaterials, the CNRs exhibit bright photoluminescence with a quantum yield of 47.0%. Furthermore, CNRs also have a large surface area and low toxicity, making them an excellent drug carrier for chemotherapeutics. A model drug molecule doxorubicin (DOX) was successfully loaded on the CNRs, and the CNRs-DOX complexes exhibit a pH-dependent DOX release behavior. Compared with free DOX, the CNRs-DOX complexes can induce a higher level of apoptosis and lower level of necrosis, showing promise as anticancer agents.
一系列的碳纳米材料，包括碳点、碳纳米环（CNRs）和多孔碳纳米球，可通过无模板的水热处理，以面筋作为唯一的碳源来简便地制备。在疏水性相互作用的驱动下，面筋在水溶液中表现出浓度依赖性的自组装，从而导致在水热处理中形成不同形态的碳纳米材料。在这些碳纳米材料中，CNRs 表现出明亮的光致发光，量子产率为 47.0%。此外，CNRs 还具有较大的表面积和较低的毒性，使其成为化疗药物的理想药物载体。模型药物分子阿霉素（DOX）成功地负载在 CNRs 上，并且 CNRs-DOX 复合物表现出 pH 依赖性的 DOX 释放行为。与游离 DOX 相比，CNRs-DOX 复合物可以诱导更高水平的细胞凋亡和更低水平的细胞坏死，有望成为抗癌药物。
