Yang Lan, Li Likang, Ji Honglei, Wang Yan, Xi Jianya, Liu Xiaofang, Xie Zhenzhen, Yuan Wei, Miao Maohua, Liang Hong
Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, School of Public Health, Fudan University, Shanghai, 200237, China.
School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China.
Environ Res. 2025 Apr 15;271:121074. doi: 10.1016/j.envres.2025.121074. Epub 2025 Feb 7.
Maternal exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with offspring adiposity; however, underlying mechanisms remain unclear. In this study, we quantified 11 PFAS in maternal plasma collected between 12 and 16 gestational weeks and 104 lipid metabolites in the cord blood of 525 mother-infant pairs. Principal components of multiple PFAS compounds, extracted by principal component analysis, were employed to investigate the effect of the PFAS mixture. Infant anthropometric indicators included weight, length, waist/arm circumference, and abdominal/triceps/subscapular skinfold thickness at birth and 6 and 12 months old. Multiple linear regression showed that maternal PFAS exposure was primarily associated with increased glycerophospholipids and decreased fatty acyls and bile acids in cord blood. Four glycerophospholipids (16:0 PI, 16:0-18:1 PI, 18:0-20:4 PI, and 18:0-18:1 PS), fatty acyls (5(S)-HETE, 15(S)-HETE, 13-HDoHE, and dhkPGF2), and bile acids (GCA, TCA, TCDA, and TDCA) partially mediated the positive associations of the first principle component of PFAS compounds (with positive loadings for all PFAS compounds), PFNA, and PFUdA with infant skinfold thickness with mediating proportions ranging from 15.24% to 33.39%. Our findings provide novel insights into mechanisms underlying the effects of maternal PFAS exposure on infant growth.
母亲暴露于全氟和多氟烷基物质（PFAS）与后代肥胖有关；然而，其潜在机制仍不清楚。在本研究中，我们对525对母婴中孕12至16周时采集的母体血浆中的11种PFAS以及脐带血中的104种脂质代谢物进行了定量分析。通过主成分分析提取的多种PFAS化合物的主成分，用于研究PFAS混合物的影响。婴儿人体测量指标包括出生时、6个月和12个月大时的体重、身长、腰围/臂围以及腹部/肱三头肌/肩胛下皮褶厚度。多元线性回归表明，母体PFAS暴露主要与脐带血中甘油磷脂增加、脂肪酰基和胆汁酸减少有关。四种甘油磷脂（16:0 PI、16:0 - 18:1 PI、18:0 - 20:4 PI和18:0 - 18:1 PS）、脂肪酰基（5(S)-HETE、15(S)-HETE、13-HDoHE和dhkPGF2）以及胆汁酸（GCA、TCA、TCDA和TDCA）部分介导了PFAS化合物第一主成分（所有PFAS化合物均为正载荷）、全氟壬酸（PFNA）和全氟十二烷酸（PFUdA）与婴儿皮褶厚度之间的正相关，中介比例范围为15.24%至33.39%。我们的研究结果为母体PFAS暴露对婴儿生长影响的潜在机制提供了新的见解。
