产前暴露于全氟和多氟烷基物质与多溴联苯醚对母婴端粒长度的混合效应。
Mixture effects of prenatal exposure to per- and polyfluoroalkyl substances and polybrominated diphenyl ethers on maternal and newborn telomere length.
机构信息
Program On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA.
Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, USA.
出版信息
Environ Health. 2021 Jun 30;20(1):76. doi: 10.1186/s12940-021-00765-4.
BACKGROUND
Per- and polyfluoroalkyl substances (PFAS) and polybrominated diphenyl ethers (PBDEs) are endocrine disrupting chemicals with widespread exposures across the U.S. given their abundance in consumer products. PFAS and PBDEs are associated with reproductive toxicity and adverse health outcomes, including certain cancers. PFAS and PBDEs may affect health through alternations in telomere length. In this study, we examined joint associations between prenatal exposure to PFAS, PBDEs, and maternal and newborn telomere length using mixture analyses, to characterize effects of cumulative environmental chemical exposures.
METHODS
Study participants were enrolled in the Chemicals in Our Bodies (CIOB) study, a demographically diverse cohort of pregnant people and children in San Francisco, CA. Seven PFAS (ng/mL) and four PBDEs (ng/g lipid) were measured in second trimester maternal serum samples. Telomere length (T/S ratio) was measured in delivery cord blood of 292 newborns and 110 second trimester maternal whole blood samples. Quantile g-computation was used to assess the joint associations between groups of PFAS and PBDEs and newborn and maternal telomere length. Groups considered were: (1) all PFAS and PBDEs combined, (2) PFAS, and (3) PBDEs. Maternal and newborn telomere length were modeled as separate outcomes.
RESULTS
T/S ratios in newborn cord and maternal whole blood were moderately correlated (Spearman ρ = 0.31). In mixtures analyses, a simultaneous one quartile increase in all PFAS and PBDEs was associated with a small increase in newborn (mean change per quartile increase = 0.03, 95% confidence interval [CI] = -0.03, 0.08) and maternal telomere length (mean change per quartile increase = 0.03 (95% CI = -0.03, 0.09). When restricted to maternal-fetal paired samples (N = 76), increasing all PFAS and PBDEs combined was associated with a strong, positive increase in newborn telomere length (mean change per quartile increase = 0.16, 95% CI = 0.03, 0.28). These associations were primarily driven by PFAS (mean change per quartile increase = 0.11 [95% CI = 0.01, 0.22]). No associations were observed with maternal telomere length among paired samples.
CONCLUSIONS
Our findings suggest that PFAS and PBDEs may be positively associated with newborn telomere length.
背景
全氟和多氟烷基物质（PFAS）和多溴二苯醚（PBDEs）是具有广泛暴露的内分泌干扰化学物质，由于它们在消费产品中的丰富存在。PFAS 和 PBDEs 与生殖毒性和不良健康后果有关，包括某些癌症。PFAS 和 PBDEs 可能通过改变端粒长度来影响健康。在这项研究中，我们使用混合分析研究了产前暴露于 PFAS、PBDEs 以及产妇和新生儿端粒长度之间的联合关联，以描述累积环境化学暴露的影响。
方法
研究参与者被纳入化学物质在我们的身体（CIOB）研究，这是一个在加利福尼亚州旧金山的孕妇和儿童的人口多样化队列。在妊娠中期母亲的血清样本中测量了七种 PFAS（ng/mL）和四种 PBDE（ng/g 脂质）。在 292 名新生儿和 110 名妊娠中期母亲全血样本的脐带血中测量了端粒长度（T/S 比值）。使用定量 g 计算来评估 PFAS 和 PBDE 与新生儿和产妇端粒长度之间的联合关联。考虑的组是：（1）所有 PFAS 和 PBDEs 组合，（2）PFAS，和（3）PBDEs。产妇和新生儿的端粒长度分别作为独立的结果进行建模。
结果
新生儿脐带和产妇全血中的 T/S 比值中度相关（Spearman ρ=0.31）。在混合物分析中，所有 PFAS 和 PBDEs 的同时一个四分位增加与新生儿端粒长度的微小增加相关（每四分位增加的平均变化=0.03，95%置信区间 [CI] =-0.03，0.08）和产妇端粒长度（每四分位增加的平均变化=0.03（95% CI=-0.03，0.09）。当限制在产妇-胎儿配对样本（N=76）时，所有 PFAS 和 PBDEs 的组合增加与新生儿端粒长度的强烈、阳性增加相关（每四分位增加的平均变化=0.16，95% CI=0.03，0.28）。这些关联主要由 PFAS 驱动（每四分位增加的平均变化=0.11 [95% CI=0.01，0.22]）。在配对样本中，未观察到与产妇端粒长度的关联。
结论
我们的研究结果表明，PFAS 和 PBDEs 可能与新生儿端粒长度呈正相关。
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