Goswami Vanshika, Sodhi Kushneet Kaur, Singh Chandra Kant
Department of Zoology, Hansraj College, University of Delhi, Delhi, 110007, India.
Department of Zoology, Sri Guru Tegh Bahadur Khalsa College, University of Delhi, Delhi, 110007, India.
Discov Nano. 2025 Feb 8;20(1):21. doi: 10.1186/s11671-025-04211-z.
In the domain of respiratory illnesses, asthma remains a critical obstacle. The heterogeneous nature of this chronic inflammatory disease poses challenges during its treatment. Glucocorticoid-based combination drug therapy now dominates clinical treatments for asthma; however, glucocorticoid resistance, numerous adverse effects, the incidence of inadequate drug delivery, and other factors need the development of more effective therapies. In recent years, there has been extensive research on nanotechnology in medicine. It has been shown in studies that these drug delivery systems can greatly enhance targeting and bioavailability and decrease the toxicity of medication. Nanoparticle drug delivery systems offer improved therapeutic efficacy compared to conventional administration techniques. Nanotechnology enables advancements in precision medicine, offering benefits for heterogeneous conditions such as asthma. This review will examine the critical factors of asthma to consider when formulating medications, as well as the role of nanomaterials and their mechanisms of action in pulmonary medicine for asthma treatment.
在呼吸系统疾病领域，哮喘仍然是一个关键障碍。这种慢性炎症性疾病的异质性在其治疗过程中带来了挑战。基于糖皮质激素的联合药物疗法目前在哮喘的临床治疗中占据主导地位；然而，糖皮质激素抵抗、众多不良反应、药物递送不足的发生率以及其他因素都需要开发更有效的疗法。近年来，医学领域对纳米技术进行了广泛研究。研究表明，这些药物递送系统可以大大提高靶向性和生物利用度，并降低药物毒性。与传统给药技术相比，纳米颗粒药物递送系统具有更高的治疗效果。纳米技术推动了精准医学的发展，为哮喘等异质性疾病带来了益处。本综述将探讨在制定药物时需要考虑的哮喘关键因素，以及纳米材料在哮喘治疗的肺部医学中的作用及其作用机制。
