Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Department of Pharmaceutics, Indore Institute of Pharmacy, IIST Campus, Rau, Indore, 453331, Madhya Pradesh, India.
Curr Med Chem. 2024;31(28):4479-4494. doi: 10.2174/0109298673258987231004092334.
Nanomedicine's application of nanotechnology in medicine holds tremendous potential for diagnosing and treating life-threatening diseases such as cancer. Unlike conventional therapies, nanomedicine offers a promising strategy to enhance clinical outcomes while minimizing severe side effects. The principle of drug targeting enables specific delivery of therapeutic agents to their intended sites, making it a more precise and effective therapy. Combination strategies, such as the co-delivery of chemotherapeutic drugs with nucleic acids or receptor-specific molecules, are being employed to enhance therapeutic outcomes. Nanocarriers and drug delivery systems designed using these approaches offer resourceful co-delivery of therapeutic agents for anticancer therapy. Targeted drug delivery via nanotechnology-based techniques has become an urgent need and has shown significant improvements in therapeutic implications, pharmacokinetics, specificity, reduced toxicity, and biocompatibility. This review discusses the extrapolation of nanomaterials for developing innovative and novel drug delivery systems for effective anticancer therapy. Additionally, we explore the role of nanotechnology-based concepts in drug delivery research.
纳米医学将纳米技术应用于医学领域，在诊断和治疗癌症等危及生命的疾病方面具有巨大的潜力。与传统疗法相比，纳米医学提供了一种有前途的策略，可以提高临床疗效，同时最大限度地减少严重的副作用。药物靶向的原理使治疗剂能够特异性地递送到其预期的部位，从而使治疗更加精确和有效。联合策略，如将化疗药物与核酸或受体特异性分子联合递送，正在被用于增强治疗效果。使用这些方法设计的纳米载体和药物递送系统为抗癌治疗提供了有创意的治疗剂共递送。基于纳米技术的靶向药物递送已成为一种迫切的需求，并在治疗意义、药代动力学、特异性、降低毒性和生物相容性方面显示出了显著的改善。本综述讨论了将纳米材料外推用于开发创新的新型药物递送系统以实现有效的抗癌治疗。此外，我们还探讨了基于纳米技术的概念在药物递送研究中的作用。
