Esmaeili Zahra, Shavali Gilani Parisa, Khosravani Masood, Motamedi Maral, Maleknejad Shokofeh, Adabi Mahdi, Sadighara Parisa
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Environmental Health Engineering, Division of Food Safety and Hygiene, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Nanomedicine (Lond). 2025 Mar;20(6):621-636. doi: 10.1080/17435889.2025.2462521. Epub 2025 Feb 9.
Epigallocatechin-3-gallate (EGCG), the primary polyphenol in green tea, is renowned for its potent antioxidant properties. EGCG interacts with various cellular targets, inhibiting cancer cell proliferation through apoptosis and cell cycle arrest induction, while also modulating metabolic pathways. Studies have demonstrated its potential in addressing cancer development, obesity, and diabetes. Given the rising prevalence of metabolic diseases and cancers, EGCG is increasingly recognized as a promising therapeutic agent. This review provides a comprehensive overview of the latest findings on the effects of both free and nano-encapsulated EGCG on mechanisms involved in the management and prevention of hyperlipidemia, diabetes, and gastrointestinal (GI) cancers. The review highlights EGCG role in modulating key signaling pathways, enhancing bioavailability through nano-formulations, and its potential applications in clinical settings.
表没食子儿没食子酸酯（EGCG）是绿茶中的主要多酚类物质，以其强大的抗氧化特性而闻名。EGCG与多种细胞靶点相互作用，通过诱导细胞凋亡和细胞周期停滞来抑制癌细胞增殖，同时还能调节代谢途径。研究表明其在应对癌症发展、肥胖和糖尿病方面具有潜力。鉴于代谢性疾病和癌症的患病率不断上升，EGCG越来越被认为是一种有前景的治疗剂。本综述全面概述了游离型和纳米包封型EGCG对参与高脂血症、糖尿病和胃肠道（GI）癌症管理与预防的机制影响的最新研究结果。该综述强调了EGCG在调节关键信号通路、通过纳米制剂提高生物利用度以及其在临床环境中的潜在应用方面的作用。
