Qiao Yujie, Liang Jiurong, Jiang Dianhua
Division of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Los Angeles, CA 90048, USA.
Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
J Respir Biol Transl Med. 2025 Mar;2(1). doi: 10.70322/jrbtm.2024.10023. Epub 2024 Dec 16.
Fibrosis is a progressive pathological process that severely impairs normal organ function. Current treatments for fibrosis are extremely limited, with no curative approaches available. In a recent article published in , Zhang and colleagues employed drug screening using ACTA2 reporter iPSC-derived cardiac fibroblasts and identified artesunate as a potent antifibrotic drug by targeting MD2/TLR4 signaling. This study provides new insights into strategies for exploiting existing drugs to treat fibrosis.
纤维化是一种进行性病理过程，会严重损害正常器官功能。目前针对纤维化的治疗方法极为有限，尚无治愈方法。在最近发表于《》的一篇文章中，张及其同事利用源自诱导多能干细胞（iPSC）的ACTA2报告基因心脏成纤维细胞进行药物筛选，并通过靶向MD2/TLR4信号通路确定青蒿琥酯为一种有效的抗纤维化药物。这项研究为开发现有药物治疗纤维化的策略提供了新的见解。
