Paul Jibon Kumar, Azmal Mahir, Haque Anm Shah Newaz Been, Meem Meghla, Talukder Omar Faruk, Ghosh Ajit
Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh.
Faculty of Medicine, Dhaka University, Dhaka 1000, Bangladesh.
World J Gastroenterol. 2025 Feb 7;31(5):99913. doi: 10.3748/wjg.v31.i5.99913.
The human gut microbiota, a complex and diverse community of microorganisms, plays a crucial role in maintaining overall health by influencing various physiological processes, including digestion, immune function, and disease susceptibility. The balance between beneficial and harmful bacteria is essential for health, with dysbiosis - disruption of this balance - linked to numerous conditions such as metabolic disorders, autoimmune diseases, and cancers. This review highlights key genera such as , , , , , , (including and ), and due to their well-established roles in immune regulation and metabolic processes, but other bacteria, including , , , and , are also implicated in dysbiosis and various diseases. Pathogenic bacteria, including and , contribute to inflammation and cancer progression by disrupting immune responses and damaging tissues. The potential for microbiota-based therapies, such as probiotics, prebiotics, fecal microbiota transplantation, and dietary interventions, to improve health outcomes is examined. Future research directions in the integration of multi-omics, the impact of diet and lifestyle on microbiota composition, and advancing microbiota engineering techniques are also discussed. Understanding the gut microbiota's role in health and disease is essential for formulating personalized, efficacious treatments and preventive strategies, thereby enhancing health outcomes and progressing microbiome research.
人类肠道微生物群是一个复杂多样的微生物群落，通过影响各种生理过程，包括消化、免疫功能和疾病易感性，在维持整体健康方面发挥着关键作用。有益菌和有害菌之间的平衡对健康至关重要，而生态失调（即这种平衡的破坏）与多种疾病相关，如代谢紊乱、自身免疫性疾病和癌症。本综述重点介绍了诸如[此处应是具体菌属名称，原文缺失]、[具体菌属名称]、[具体菌属名称]、[具体菌属名称]、[具体菌属名称]、[具体菌属名称]、[具体菌属名称]（包括[具体菌属名称]和[具体菌属名称]）以及[具体菌属名称]等关键菌属，因为它们在免疫调节和代谢过程中已确立的作用，但其他细菌，包括[具体菌属名称]、[具体菌属名称]、[具体菌属名称]和[具体菌属名称]，也与生态失调和各种疾病有关。包括[具体病原菌名称]和[具体病原菌名称]在内的病原菌，通过破坏免疫反应和损伤组织，导致炎症和癌症进展。研究了基于微生物群的疗法，如益生菌、益生元、粪便微生物群移植和饮食干预改善健康结果的潜力。还讨论了多组学整合的未来研究方向、饮食和生活方式对微生物群组成的影响以及推进微生物群工程技术。了解肠道微生物群在健康和疾病中的作用对于制定个性化、有效的治疗方法和预防策略至关重要，从而提高健康结果并推动微生物组研究的进展。
