Molenaar D, Verdonck-de Leeuw I M, Lissenberg-Witte B I, Takes R P, de Bree R, Langendijk J A, Hardillo J A, Lamers F, Leemans C R, Jansen F
Cancer Center Amsterdam Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Department of Otolaryngology-Head and Neck Surgery, VUmc Cancer Center Amsterdam, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
J Cancer Surviv. 2025 Feb 10. doi: 10.1007/s11764-025-01753-0.
To investigate which demographic, personal, clinical, physical, psychological, social, lifestyle, and cancer-related quality of life (QoL) factors are associated with (changes in) supportive care needs (SCNs) from 6 months to 2 years after treatment in head and neck cancer (HNC) patients.
Data from the prospective NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) study among HNC patients treated with curative intent was used. SCNs were measured using the Supportive Care Needs Survey 34-item Short-Form (SCNS-SF34) (6 months, 1 and 2 years after treatment) and the 11-item HNC-specific module (SCNS-HNC) (2 years). Multivariable linear mixed model analyses and linear regression analyses were used to study factors associated with changes in SCNs over time (SCNS-SF34) and the level of SCNs at 2 years follow-up (SCNS-SF34 and SCNS-HNC).
Data from 483 patients was used. SCNs in the physical and daily living (PDL), psychological (PSY), and health system, information, and patient support (HSIPS) domains decreased significantly over time. At 2 years follow-up, the highest SCNs were reported regarding lack of energy/tiredness (10.8%). Changes in SCNs and the absolute level of SCNs at 2 years were associated with personal and clinical factors and post-treatment (6 months) with psychological, lifestyle, and cancer-related QoL factors.
Personal, clinical, psychological, lifestyle, and cancer-related QoL factors were associated with SCNs. These results can be used to develop predictive models to personalize supportive care for HNC patients.
SCNs decrease over time, but a subgroup of patients still presents with SCNs 2 years after treatment.
探讨哪些人口统计学、个人、临床、身体、心理、社会、生活方式和癌症相关生活质量（QoL）因素与头颈癌（HNC）患者治疗后6个月至2年的支持性护理需求（SCNs）（变化）相关。
使用来自荷兰前瞻性生活质量和生物医学队列（NET-QUBIC）研究的数据，该研究针对接受根治性治疗的HNC患者。使用支持性护理需求调查34项简表（SCNS-SF34）（治疗后6个月、1年和2年）和11项HNC特定模块（SCNS-HNC）（2年）测量SCNs。多变量线性混合模型分析和线性回归分析用于研究与SCNs随时间变化（SCNS-SF34）以及2年随访时SCNs水平（SCNS-SF34和SCNS-HNC）相关的因素。
使用了483名患者的数据。身体和日常生活（PDL）、心理（PSY）以及卫生系统、信息和患者支持（HSIPS）领域的SCNs随时间显著下降。在2年随访时，报告缺乏能量/疲劳的SCNs最高（10.8%）。SCNs的变化以及2年时SCNs的绝对水平与个人和临床因素以及治疗后（6个月）与心理、生活方式和癌症相关QoL因素有关。
个人、临床、心理、生活方式和癌症相关QoL因素与SCNs相关。这些结果可用于开发预测模型，以实现HNC患者支持性护理的个性化。
SCNs随时间下降，但仍有一部分患者在治疗后2年仍存在SCNs。
