中国眼部肿瘤患者的健康相关生活质量及其影响因素
Health related quality of life and its influencing factors in Chinese patients with ocular tumors.
作者信息
Zhang Yongmei, Peng Wen, Zhao Xiaojun, Zhu Yiwen, Chen Huifang
机构信息
Department of Nursing, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
出版信息
Sci Rep. 2025 Feb 10;15(1):4927. doi: 10.1038/s41598-025-88747-1.
BACKGROUND
Ocular tumors are a class of important ophthalmologic diseases that threaten patient visual acuity and health-related quality of life (HRQoL). However, little is known about the factors affecting HRQoL among individuals with ocular tumors in mainland China.
METHODS
Convenience sampling was employed to select 144 patients with ocular tumors being treated in a grade A tertiary hospital in Shanghai from August 2022 to May 2023 as study participants. A self-made general data questionnaire, the Medical Coping Modes Questionnaire (MCMQ), Fear of Progression Questionnaire Short Form (FoP-Q-SF), and Euro-Qol-5 Dimensions (EQ-5D-3 L) were used to conduct a cross-sectional survey. Multiple linear regression was performed to analyze the factors affecting QoL.
RESULTS
The mean EQ-5D-3 L visual analog score was 81.60 ± 17.66 and the most common problems reported by patients with ocular tumors were pain, discomfort, anxiety, and depression. The total MCMQ score was 39.88 ± 7.04, and the total FoP-Q-SF score was 25.24 ± 9.27. The health effects index was negatively correlated with avoidance (r = - 0.226, p < 0.05) and resignation dimensions (r = - 0.460, p < 0.05) and negatively correlated with total FoP-Q-SF score (r = - 0.491, p < 0.001). Multiple linear regression analysis showed that having a resignation coping style, high FOP, low visual acuity in the non-dominant eye, and diagnosis of malignant tumor is significantly associated with low HRQoL ( p < 0.05).
CONCLUSIONS
The HRQoL of patients with ocular tumors tends to be low. HRQoL in these patients is associated with increased MCMQ resignation domain score, FoP-Q-SF physical health domain score, definitive diagnosis of malignancy, and decreases in non-dominant eye visual acuity. We recommend that clinical staff focus on improving non-dominant eye visual acuity in patients with ocular tumors and improve their disease coping styles to decrease FOP, thereby increasing their QoL.
背景
眼部肿瘤是一类重要的眼科疾病，会威胁患者的视力和健康相关生活质量（HRQoL）。然而，关于中国大陆眼部肿瘤患者中影响HRQoL的因素，人们了解甚少。
方法
采用便利抽样法，选取2022年8月至2023年5月在上海一家三级甲等医院接受治疗的144例眼部肿瘤患者作为研究对象。使用自制的一般资料问卷、医学应对方式问卷（MCMQ）、恐惧疾病进展简化问卷（FoP-Q-SF）和欧洲五维健康量表（EQ-5D-3L）进行横断面调查。采用多重线性回归分析影响生活质量的因素。
结果
EQ-5D-3L视觉模拟评分的平均值为81.60±17.66，眼部肿瘤患者报告的最常见问题是疼痛、不适、焦虑和抑郁。MCMQ总分是39.88±7.04，FoP-Q-SF总分是25.24±9.27。健康影响指数与回避维度（r = -0.226，p < 0.05）和屈服维度（r = -0.460，p < 0.05）呈负相关，与FoP-Q-SF总分呈负相关（r = -0.491，p < 0.001）。多重线性回归分析显示，采用屈服应对方式、高恐惧疾病进展、非优势眼低视力以及诊断为恶性肿瘤与低HRQoL显著相关（p < 0.05）。
结论
眼部肿瘤患者的HRQoL往往较低。这些患者的HRQoL与MCMQ屈服维度得分增加、FoP-Q-SF身体健康维度得分增加、确诊为恶性肿瘤以及非优势眼视力下降有关。我们建议临床工作人员关注提高眼部肿瘤患者的非优势眼视力，并改善他们应对疾病的方式以降低恐惧疾病进展，从而提高他们的生活质量。
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