The College of Nursing and Health of Zhengzhou University, Zhengzhou, 450001, China.
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Support Care Cancer. 2022 Dec;30(12):9889-9899. doi: 10.1007/s00520-022-07451-2. Epub 2022 Nov 19.
The status and associated factors of the health-related quality of life of non-small-cell lung cancer (NSCLC) patients under targeted anti-cancer therapy have not been investigated. Self-management and coping style have been proven to be closely related to patients' health-related quality of life. Based on these observations, this study was designed to firstly assess the status of health-related quality of life, and then explore the relationships among coping styles, self-management, and health-related quality of life of NSCLC patients with skin adverse drug reactions under targeted therapy.
We performed a cross-sectional study including 536 NSCLC patients with skin adverse drug reactions under targeted therapy in cancer clinics of three hospitals in China between May 2020 and May 2021. Structured questionnaires, including the Functional Assessment of Cancer Therapy-Epidermal Growth Factor Receptor Inhibitor 18, Cancer Patient Self-management Evaluation Scale, and Medical Coping Modes Questionnaire, were used to collect data. Relationships among coping style, self-management, and health-related quality of life were identified by Pearson correlation analysis and a multiple linear regression algorithm.
The total score of health-related quality of life was 46 ± 12.84 in 536 NSCLC patients with skin adverse drug reactions undergoing targeted therapy. Health-related quality of life was positively correlated with self-management (r = 0.785, P < 0.01) and facing (r = 0.807, P < 0.01) and negatively correlated with yield (r = - 0.718, P < 0.01), avoidance (r = - 0.711, P < 0.01), and the severity of skin adverse reactions (r = - 0.722, P = 0.000). Via multiple linear regression analysis, we identified some significant factors associated with health-related quality of life, including age, education level, combination of medicine, Charlson Comorbidity Index, stages of disease, facing, yield, symptom management, daily activity management, psychological and emotional management, self-efficacy, and self-management (P < 0.05).
NSCLC patients with skin adverse drug reactions undergoing targeted therapy generally had a compromised health-related quality of life. The critical factors that were associated with the status of health-related quality of life were age, education level, comorbidity, the combinatorial application of drugs, stage of disease, self-management, and coping styles.
针对接受靶向抗癌治疗的非小细胞肺癌（NSCLC）患者的健康相关生活质量状况及其相关因素，目前尚未开展相关研究。自我管理和应对方式已被证明与患者的健康相关生活质量密切相关。基于这些观察结果，本研究旨在首先评估健康相关生活质量的状况，然后探讨接受靶向治疗的 NSCLC 患者皮肤不良反应的应对方式、自我管理与健康相关生活质量之间的关系。
本研究为横断面研究，纳入了 2020 年 5 月至 2021 年 5 月在中国 3 家医院癌症门诊接受靶向治疗的 536 例 NSCLC 皮肤不良反应患者。采用功能评估癌症治疗-表皮生长因子受体抑制剂 18、癌症患者自我管理评估量表和医学应对方式问卷等结构问卷收集数据。采用 Pearson 相关分析和多元线性回归算法，确定应对方式、自我管理与健康相关生活质量之间的关系。
536 例接受靶向治疗的 NSCLC 皮肤不良反应患者的健康相关生活质量总分为（46±12.84）分。健康相关生活质量与自我管理呈正相关（r=0.785，P<0.01），与屈服（r= -0.718，P<0.01）、回避（r= -0.711，P<0.01）呈负相关，与应对方式（r=0.807，P<0.01）呈正相关。通过多元线性回归分析，我们确定了一些与健康相关生活质量显著相关的因素，包括年龄、教育水平、药物联合应用、Charlson 合并症指数、疾病分期、应对方式、屈服、症状管理、日常活动管理、心理和情绪管理、自我效能和自我管理（P<0.05）。
接受靶向治疗的 NSCLC 皮肤不良反应患者的健康相关生活质量普遍较差。与健康相关生活质量状况相关的关键因素是年龄、教育水平、合并症、药物联合应用、疾病分期、自我管理和应对方式。
