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芍药花的综合化学与生物活性研究：以将中药副产物转化为新型食品成分为例

Comprehensive chemical and bioactive investigation of Chinese peony flower: a case of valorization of by-products as a new food ingredient from Chinese herb.

作者信息

Peng Meng-Ling, Gong Ming-Jiong, Zhang Jing, Gadetskaya Anastassiya V, Liang Qian-Wen, He Pei-Wen, Qiu Xiao-Hui, Huang Zhi-Hai, Xu Wen

机构信息

State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

School of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan.

出版信息

Front Plant Sci. 2025 Jan 27;15:1501966. doi: 10.3389/fpls.2024.1501966. eCollection 2024.

DOI:10.3389/fpls.2024.1501966
PMID:39931332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11808149/
Abstract

INTRODUCTION

In the present study, the flower of Chinese peony (CPF), major waste by-product of Chinese Herb , was comprehensively investigated for the first time.

METHODS

A validated UHPLC Orbitrap Mass spectrometry combined a three-levels characterization strategy were used to analyze CPF samples from four representative cultivars. The anti-inflammatory and antioxidant activities were analyzed using RAW264.7 cells, and DPPH, ABTS, FRAP, and ORAC antioxidant assays.

RESULTS

A total of 150 chemical components were identified in CPF, among them, more than 50 components were reported from this species for the first time, with potential new chemicals reported. 67 quantified or semi-quantified targeted metabolomics analysis indicated a clear distinction between flower parts and four cultivars. CPF demonstrated significant antioxidant activities and displayed anti-inflammatory effects by reducing nitric oxide, IL-6, and TNF-a release in LPS-induced macrophages. Correlation analysis highlighted a strong positive correlation between total phenolic content and DPPH ABTS, and FRAP antioxidant activities.

DISCUSSION

The present study is the first to comprehensively investigate the chemical profile and bioactivities of CPF, which provide insights into further understanding of its health-promoting potential.

摘要

引言

在本研究中，首次对芍药花（CPF）进行了全面研究，芍药花是中药的主要废弃副产品。

方法

采用经过验证的超高效液相色谱-轨道阱质谱联用三级表征策略，分析来自四个代表性品种的CPF样品。使用RAW264.7细胞以及DPPH、ABTS、FRAP和ORAC抗氧化测定法分析其抗炎和抗氧化活性。

结果

在CPF中总共鉴定出150种化学成分，其中有50多种成分是首次从该物种中报道，还有潜在的新化学物质被报道。67种定量或半定量的靶向代谢组学分析表明花的不同部位和四个品种之间存在明显差异。CPF表现出显著的抗氧化活性，并通过减少脂多糖诱导的巨噬细胞中一氧化氮、白细胞介素-6和肿瘤坏死因子-α的释放而显示出抗炎作用。相关性分析突出了总酚含量与DPPH、ABTS和FRAP抗氧化活性之间的强正相关。

讨论

本研究首次全面研究了CPF的化学特征和生物活性，为进一步了解其促进健康的潜力提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/a19e4c9e6f4c/fpls-15-1501966-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/60b304a49bd9/fpls-15-1501966-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/695ca9967b7a/fpls-15-1501966-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/d3ca71aa5e57/fpls-15-1501966-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/9a697f51c56d/fpls-15-1501966-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/a19e4c9e6f4c/fpls-15-1501966-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/60b304a49bd9/fpls-15-1501966-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/695ca9967b7a/fpls-15-1501966-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/d3ca71aa5e57/fpls-15-1501966-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/9a697f51c56d/fpls-15-1501966-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a31/11808149/a19e4c9e6f4c/fpls-15-1501966-g005.jpg

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