Yang Pan, Li Jing, Ma Xiumei, Hu Nan, Song Zhangyong, Chen Bin, Li Shizhu
Postdoctoral Research Station, Guangzhou Bay Area Institute of Biomedicine, Guangzhou, China.
School of Basic Medical Sciences, Southwest Medical University, Luzhou, China.
Front Microbiol. 2025 Jan 27;16:1526096. doi: 10.3389/fmicb.2025.1526096. eCollection 2025.
Currently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug delivery systems (i.e., hydrogel, liposomes, electrospun fibers, nanoparticles and nanoemulsion) for phages and their encoded lysins in WI management has become a hot topic. To assess the current landscape of these emerging technologies, we conducted a comprehensive literature search across PubMed, Scopus and Web of Science up to July 2024, using terms such as "phage," "lysin," "wound," "hydrogel," "liposomes," "fibers," "nanoparticles," and "nanoemulsion." The criteria included original studies of five novel delivery systems for phages and lysins in WI management. The findings highlighted the positive effects of the five novel delivery systems for phages and lysins in WI management, significantly reducing wound bacterial populations, and accelerating healing at the injury site. However, the available literature on novel delivery systems for phages and lysins remains limited, particularly for lysins. In conclusion, the application of novel drug delivery systems for phages and lysins showed great potential in combating MDR bacterial WIs.
目前，耐多药（MDR）细菌伤口感染（WI）对医生来说是一个极具挑战性的临床问题。最近，与传统的单一液体给药药物相比，研究用于噬菌体及其编码溶菌酶以处理伤口感染的五种新型药物递送系统（即水凝胶、脂质体、电纺纤维、纳米颗粒和纳米乳液）已成为一个热门话题。为了评估这些新兴技术的现状，我们在截至2024年7月期间，在PubMed、Scopus和Web of Science上进行了全面的文献检索，使用了“噬菌体”、“溶菌酶”、“伤口”、“水凝胶”、“脂质体”、“纤维”、“纳米颗粒”和“纳米乳液”等术语。纳入标准包括关于噬菌体和溶菌酶在伤口感染处理中的五种新型递送系统的原始研究。研究结果突出了噬菌体和溶菌酶的五种新型递送系统在伤口感染处理中的积极作用，显著减少伤口细菌数量，并加速损伤部位的愈合。然而，关于噬菌体和溶菌酶新型递送系统的现有文献仍然有限，特别是关于溶菌酶的文献。总之，噬菌体和溶菌酶新型药物递送系统的应用在对抗耐多药细菌伤口感染方面显示出巨大潜力。
