Lake Erie College of Osteopathic Medicine, Bradenton, Florida, USA.
Department of Chemistry, Iswar Chandra Vidyasagar College, Belonia, Tripura, India.
Crit Rev Food Sci Nutr. 2021;61(13):2125-2151. doi: 10.1080/10408398.2020.1771678. Epub 2020 Jun 8.
L. (mango), a long-living evergreen plant belonging to the Anacardiaceae family, has been cultivated for thousands of years in the Indian subcontinent for its excellent fruits which represent a rich source of fiber, vitamin A and C, essential amino acids, and a plethora of phytochemicals. is extensively used in various traditional systems of medicine to prevent and treat several diseases. The health-promoting and disease-preventing effects of are attributed to a number of bioactive phytochemicals, including polyphenols, terpenoids, carotenoid and phytosterols, found in the leaf, bark, edible flesh, peel, and seed. has been shown to exhibit various biological and pharmacological activities, such as antioxidant, anti-inflammatory, immunomodulatory, antimicrobial, antidiabetic, antiobesity, and anticancer effects. There are a few studies conducted that have indicated the nontoxic nature of mango constituents. However, while there are numerous individual studies investigating anticancer effects of various constituents from the mango tree, an up-to-date, comprehensive and critical review of available research data has not been performed according to our knowledge. The purpose of this review is to present a comprehensive and critical evaluation of cancer preventive and anticancer therapeutic potential of and its phytochemicals with special focus on the cellular and molecular mechanisms of action. The bioavailability, pharmacokinetics, and safety profile of individual phytocomponents of as well as current limitations, challenges, and future directions of research have also been discussed.
L.（芒果）是漆树科的一种长寿常绿植物，在印度次大陆已经被种植了几千年，因其优良的果实而闻名，这些果实富含纤维、维生素 A 和 C、必需氨基酸和大量植物化学物质。在各种传统医学体系中，广泛用于预防和治疗多种疾病。 被认为具有促进健康和预防疾病的作用，这归因于其所含的多种生物活性植物化学物质，包括多酚、三萜类、类胡萝卜素和植物固醇，这些物质存在于叶子、树皮、可食用果肉、果皮和种子中。 已被证明具有多种生物学和药理学活性，如抗氧化、抗炎、免疫调节、抗菌、抗糖尿病、抗肥胖和抗癌作用。有一些研究表明芒果成分具有非毒性。然而，虽然有许多单独的研究调查了芒果树中各种成分的抗癌作用，但据我们所知，尚未对现有研究数据进行全面、综合和批判性的综述。本综述的目的是全面、批判性地评估 及其植物化学物质的预防癌症和抗癌治疗潜力，特别关注其作用的细胞和分子机制。还讨论了 个别植物成分的生物利用度、药代动力学和安全性概况，以及当前研究的局限性、挑战和未来方向。
