碘介导的 N-硫代酰基-1-(2-吡啶基)-1,2-氨基醇的环化及其随后的缩合导致新型双(1-咪唑并[1,5-a]吡啶基)芳基甲烷的形成。
Iodine-mediated cyclization of N-thioacyl-1-(2-pyridyl)-1,2-aminoalcohols and their subsequent condensation leading to the formation of novel bis(1-imidazo[1,5-a]pyridyl)arylmethanes.
机构信息
Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan.
出版信息
Chem Commun (Camb). 2009 Dec 7(45):7009-11. doi: 10.1039/b910172a. Epub 2009 Oct 13.
DOI:10.1039/b910172a
PMID:19904377
Abstract
The treatment of N-thioacyl-1-(2-pyridyl)-1,2-aminoalcohols with iodine and pyridine in THF at room temperature for 30 min leads to the formation of bis(1-imidazo[1,5-a]pyridyl)arylmethanes as green solids in good to high yields.
摘要
室温下，N-硫代酰基-1-(2-吡啶基)-1,2-氨基醇在四氢呋喃中与碘和吡啶反应 30 分钟，生成双(1-咪唑并[1,5-a]吡啶基)芳基甲烷，作为绿色固体，以良好到高产率得到。
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