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光氧化还原催化的醇到亚磺酰胺的脱氧自由基转化反应。

Photoredox-catalyzed deoxygenative radical transformation of alcohols to sulfinamides.

作者信息

Zhu Xinyu, Wu Junliang, Zhang Junliang, Yang Junfeng

机构信息

Henan Institute of Advanced Technology, Zhengzhou University Zhengzhou 450001 China

Department of Chemistry, Fudan University 2005 Songhu Road Shanghai 200438 China

出版信息

RSC Adv. 2025 Feb 10;15(6):4532-4535. doi: 10.1039/d5ra00158g. eCollection 2025 Feb 6.

Abstract

Sulfinamides play a crucial role in organic synthesis and pharmaceuticals. In this study, we introduce a highly effective method for the deoxygenative radical addition to -tritylsulfinylamine, which produces sulfinamides photoredox catalysis. This method is compatible with a diverse array of functional groups and the resulting sulfonamides were achieved in moderate to high yields. Furthermore, the synthetic applications to access various sulfur(vi)-centered functional groups highlight the practicality of this approach.

摘要

亚磺酰胺在有机合成和药物领域发挥着关键作用。在本研究中,我们介绍了一种向三苯基亚磺酰亚胺进行脱氧自由基加成的高效方法,该方法通过光氧化还原催化生成亚磺酰胺。此方法与多种官能团兼容,所得磺酰胺的产率为中等至较高。此外,用于合成各种以硫(VI)为中心的官能团的应用突出了该方法的实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5034/11808478/1ec9173bf515/d5ra00158g-f1.jpg

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