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撤稿声明:MUC1-C癌蛋白在尿路上皮癌获得顺铂耐药性中的作用。

RETRACTION: Role of the MUC1-C Oncoprotein in the Acquisition of Cisplatin Resistance by Urothelial Carcinoma.

出版信息

Cancer Sci. 2025 Apr;116(4):1154. doi: 10.1111/cas.70016. Epub 2025 Feb 11.

DOI:10.1111/cas.70016
PMID:39932034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11967264/
Abstract

K. Shigeta, M. Hasegawa, E. Kikuchi, Y. Yasumizu, T. Kosaka, R. Mizuno, S. Mikami, A. Miyajima, D. Kufe and M. Oya, "Role of the MUC1-C Oncoprotein in the Acquisition of Cisplatin Resistance by Urothelial Carcinoma," Cancer Science 111, no. 10 (2020): 3639-3652, https://doi.org/10.1111/cas.14574. The above article, published online on 16 July 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Masanori Hatakeyama; the Japanese Cancer Association; and John Wiley & Sons Australia Ltd. The retraction has been agreed upon due to several instances of duplications of western blot bands observed between Figures 2E and 3B; 4A and 4D; S1b and S3a; and within S1d. The authors commented that this was due to inadvertent errors and provided some data including replacement images. However, the data supplied did not meet acceptable standards for raw data and the editors were not satisfied with the explanation provided. Due to the extent of the errors, the editors have lost confidence in the results and conclusions of this study. The authors disagree with the retraction.

摘要

K. 重田、长谷川真、菊池英、安水洋、小坂彻、水野润、三上史、宫岛淳、库费·D. 和大矢真,“MUC1-C癌蛋白在上皮性膀胱癌获得顺铂耐药性中的作用”,《癌症科学》111卷,第10期(2020年):3639 - 3652页,https://doi.org/10.1111/cas.14574 。上述文章于2020年7月16日在线发表于威利在线图书馆(wileyonlinelibrary.com),已由期刊主编畠山正宪、日本癌症协会以及约翰·威利父子澳大利亚有限公司达成协议予以撤回。撤回是因为在图2E与3B之间、4A与4D之间、S1b与S3a之间以及S1d内部观察到多次蛋白质免疫印迹条带重复的情况。作者称这是由于疏忽性错误,并提供了一些数据,包括替换图像。然而,所提供的数据不符合原始数据的可接受标准,编辑们对所提供的解释也不满意。由于错误的程度,编辑们对该研究的结果和结论失去了信心。作者不同意撤回。