Univ. Bordeaux, INSERM, BPH, U1219, F-33000 Bordeaux, France; Activ'Inside, 33750 Beychac-et-Caillau, France.
Activ'Inside, 33750 Beychac-et-Caillau, France.
J Affect Disord. 2023 Oct 15;339:615-623. doi: 10.1016/j.jad.2023.07.076. Epub 2023 Jul 17.
As part of a healthy diet, higher carotenoid intakes have been associated with a reduced risk of depression, mainly in adults, while prospective studies on plasma carotenoids in older adults are lacking. The aim of this study was to assess the prospective association between plasma carotenoids and the risk of Depressive Symptomatology (DS) in older adults.
The study sample was based on the Three-City cohort of adults aged 65y+ free from DS at enrollment in 1999. Plasma carotenoids were measured at baseline. DS was assessed every 2-3 years over 17 years and defined by a Center for Epidemiologic Studies-Depression Scale score ≥ 16 and/or by antidepressant use. The association between plasma carotenoids or carotenoid/lipids (cholesterol and triglycerides) ratio and the risk for DS was assessed through multiple random-effect logistic regression.
The study sample was composed of 1010 participants (mean age 74 y (±4.9), 58 % of women) followed-up during a median time of 13.4 years. Plasma zeaxanthin and ratios of zeaxanthin/lipids, lutein+zeaxanthin/lipids and β-carotene/lipids were independently associated with a significant reduced risk of DS over time (Odds ratio (OR) = 0.81, 95 % Confidence Interval (CI) [0.67;0.99], OR = 0.79 [0.67;0.98], OR = 0.79 [0.64;0.94] and OR = 0.80 [0.66;0.97] for +1 standard deviation of each exposure respectively).
Plasma carotenoids were only available at study baseline.
Focusing on circulating carotenoids and considering lipids levels, the present results suggested an association between higher levels of plasma zeaxanthin, combined lutein+zeaxanthin and β-carotene and a decreased risk of DS over time in older adults.
作为健康饮食的一部分，较高的类胡萝卜素摄入量与抑郁症风险降低有关，主要在成年人中，而针对老年人血浆类胡萝卜素的前瞻性研究则较为缺乏。本研究旨在评估老年人血浆类胡萝卜素与抑郁症状（DS）风险之间的前瞻性关联。
本研究样本基于 1999 年无 DS 的 65 岁及以上成年人的三城市队列。在基线时测量血浆类胡萝卜素。在 17 年内每 2-3 年评估一次 DS，并通过使用中心流行病学研究-抑郁量表评分≥16 分和/或使用抗抑郁药来定义。通过多随机效应逻辑回归评估血浆类胡萝卜素或类胡萝卜素/脂质（胆固醇和甘油三酯）比值与 DS 风险之间的关联。
本研究样本由 1010 名参与者组成（平均年龄 74 岁（±4.9），58%为女性），中位随访时间为 13.4 年。血浆玉米黄质和玉米黄质/脂质、叶黄素+玉米黄质/脂质和β-胡萝卜素/脂质的比值与 DS 的风险随时间呈显著负相关（比值比（OR）=0.81，95%置信区间（CI）[0.67;0.99]，OR=0.79 [0.67;0.98]，OR=0.79 [0.64;0.94]和 OR=0.80 [0.66;0.97]，分别为每个暴露因素增加一个标准差）。
仅在研究基线时获得血浆类胡萝卜素。
本研究结果提示，在老年人中，血浆玉米黄质水平较高，叶黄素+玉米黄质和β-胡萝卜素水平较高与抑郁症状风险降低有关，且考虑到脂质水平，该结果具有统计学意义。
