Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun 130021, China.
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
J Affect Disord. 2023 Feb 15;323:264-279. doi: 10.1016/j.jad.2022.11.072. Epub 2022 Nov 25.
New research supports an integrated approach to treating depression, and lifestyle modifications should be a regular component of both preventative and treatment programs. Therefore, in order to investigate the relationship between various antioxidant supplements and depressive status, we carried out a meta-analysis of randomized controlled trials (RCT).
We thoroughly searched PubMed, Medline, Scopus, and Web of Science databases to screen publications focusing on the effects of antioxidant supplements on depression status. The meta-analysis mainly compared depression scores between groups that received antioxidant supplements and controls. We also pooled studies reporting changes in anxiety status as a secondary outcome.
52 studies with 4049 participants were eventually identified. The meta-analysis found that the positive effect of antioxidant supplementation, such as magnesium (SMD = 0.16, p = 0.03), zinc (SMD = 0.59, p = 0.01), selenium (SMD = 0.33, p = 0.009), CoQ10 (SMD = 0.97, p = 0.05), tea and coffee (SMD = 1.15, p = 0.001) and crocin (MD = 6.04, p < 0.00001), on depressive status were all significant. And antioxidant supplementation also showed significant improvement in anxiety (SMD = 0.40, p < 0.00001). Subgroup analysis by scale types and countries were performed, and antioxidant supplementation's positive effects on depressive and anxiety states remained significant.
This study did not limit the characteristics of the included population, and the diversity of scales also contributed to the heterogeneity.
Intake of antioxidant supplements is associated with improved depression and anxiety states, further affirms the therapeutic potential of antioxidant supplements as adjunctive therapy to conventional antidepressants.
新的研究支持采用综合方法治疗抑郁症，生活方式的改变应该成为预防和治疗计划的常规组成部分。因此，为了研究各种抗氧化补充剂与抑郁状态之间的关系，我们对随机对照试验（RCT）进行了荟萃分析。
我们彻底搜索了 PubMed、Medline、Scopus 和 Web of Science 数据库，以筛选关注抗氧化补充剂对抑郁状态影响的出版物。荟萃分析主要比较了接受抗氧化补充剂和对照组的抑郁评分。我们还汇总了报告焦虑状态变化的研究作为次要结果。
最终确定了 52 项研究，共 4049 名参与者。荟萃分析发现，抗氧化补充剂的积极作用，如镁（SMD=0.16，p=0.03）、锌（SMD=0.59，p=0.01）、硒（SMD=0.33，p=0.009）、CoQ10（SMD=0.97，p=0.05）、茶和咖啡（SMD=1.15，p=0.001）和西红花酸（MD=6.04，p<0.00001），对抑郁状态均有显著影响。抗氧化补充剂对焦虑状态也有显著改善（SMD=0.40，p<0.00001）。按量表类型和国家进行亚组分析，抗氧化补充剂对抑郁和焦虑状态的积极作用仍然显著。
本研究没有限制纳入人群的特征，量表的多样性也导致了异质性。
摄入抗氧化补充剂与改善抑郁和焦虑状态有关，进一步证实了抗氧化补充剂作为传统抗抑郁药辅助治疗的治疗潜力。
