Pasek M, Goto T, Gilbert W, Zink B, Schaller H, MacKay P, Leadbetter G, Murray K
Nature. 1979 Dec 6;282(5739):575-9. doi: 10.1038/282575a0.
A composite DNA sequence of regions of hepatitis B virus, determined from a series of recombinant plasmids, reveals the genes for the surface antigen and the core antigen of the virus. The sequence of the core antigen shows it to be a DNA binding protein. The core antigen gene is expressed in Escherichia coli and when injected into rabbits the bacterial product induces antibodies which react with core antigen isolated from human sources.
从一系列重组质粒中确定的乙肝病毒区域的复合DNA序列，揭示了该病毒表面抗原和核心抗原的基因。核心抗原序列显示其为一种DNA结合蛋白。核心抗原基因在大肠杆菌中表达，将细菌产物注入兔子体内时，会诱导产生与从人类来源分离的核心抗原发生反应的抗体。
