Lai Tianjie, Su Zhihao, Chen Rui, Luo Guangan, Xu Sibo, Fang Hangqi, Yan Huanxin, Shen Peng, Hu Konghe
Department of Spine Surgery, The Affiliated Yuebei People's Hospital of Shantou University Medical College, Shaoguan, Guangdong, P.R. China.
First Clinical Medical College, Guangdong Medical University, Zhanjiang, China.
PLoS One. 2025 Feb 11;20(2):e0318356. doi: 10.1371/journal.pone.0318356. eCollection 2025.
The triglyceride-glucose (TyG) index and its related indexes (TyG-BMI, TyG-WC, TyG-WHtR) are effective markers for screening metabolic diseases like insulin resistance (IR). However, few studies have explored the relationship between the TyG and its related indexes with bone density (BMD), osteopenia, and osteoporosis. This is a cross-sectional study that involved 1,303 adults aged 50 years and above from the National Health and Nutrition Examination Survey 2007-2010, and 2013-2014. In the multivariable-adjusted model, linear regression analysis and logistic regression analysis demonstrated that TyG and its related indexes have a significant positive correlation with BMD and a negative correlation with osteopenia/osteoporosis in the femoral neck, lumbar spine, and total hip region. Trend analysis further confirms these associations (p < 0.05). Restricted cubic spline analysis showed a nonlinear relationship between these indexes with BMD and osteopenia/osteoporosis. Sensitivity analyses further confirmed the robustness of these associations. This study reveals the significant and complex correlation between the TyG and its related indexes with BMD and osteoporosis, indicating the potential link between IR and bone health. The TyG and related indexes offer a new perspective for the diagnosis, prevention, and treatment of osteoporosis.
甘油三酯-葡萄糖（TyG）指数及其相关指数（TyG-BMI、TyG-WC、TyG-WHtR）是筛查胰岛素抵抗（IR）等代谢性疾病的有效指标。然而，很少有研究探讨TyG及其相关指数与骨密度（BMD）、骨质减少和骨质疏松症之间的关系。这是一项横断面研究，纳入了2007 - 2010年以及2013 - 2014年美国国家健康与营养检查调查中1303名50岁及以上的成年人。在多变量调整模型中，线性回归分析和逻辑回归分析表明，TyG及其相关指数与股骨颈、腰椎和全髋区域的骨密度呈显著正相关，与骨质减少/骨质疏松症呈负相关。趋势分析进一步证实了这些关联（p < 0.05）。受限立方样条分析显示这些指数与骨密度和骨质减少/骨质疏松症之间存在非线性关系。敏感性分析进一步证实了这些关联的稳健性。本研究揭示了TyG及其相关指数与骨密度和骨质疏松症之间显著而复杂的相关性，表明IR与骨骼健康之间存在潜在联系。TyG及其相关指数为骨质疏松症的诊断、预防和治疗提供了新的视角。
