Bondestam M, Funa K, Alm G V
Acta Paediatr Scand. 1985 Mar;74(2):219-25. doi: 10.1111/j.1651-2227.1985.tb10953.x.
Children with recurrent and/or unusually severe infections were investigated for possible defects in the interferon (IFN)-natural killer (NK) cell system. Two series, each of 13 children, were examined, one in 1982 and one in 1983. Healthy children, seven in 1982 and eight in 1983, served as controls. Peripheral blood mononuclear leukocytes were examined for IFN production induced by the IFN-alpha inducers Sendai virus and Escherichia coli and by the IFN-gamma inducers Concanavalin A and Lens culinaris lectin. None of these inducers discriminated patients from controls. However, the bacteria Staphylococcus aureus Cowan I (SACol), inducers of atypical IFN in null lymphocytes, yielded significantly lower IFN production in infection-prone children than in controls, particularly in children with recurrent infections accompanied by arthralgia. No differences in basal NK activity or in the in vitro enhancement of such activity by IFN-alpha were found between patients and controls.
对患有复发性和/或异常严重感染的儿童进行了干扰素（IFN）-自然杀伤（NK）细胞系统潜在缺陷的调查。研究了两个系列，每个系列13名儿童，一个系列于1982年进行，另一个系列于1983年进行。健康儿童作为对照，1982年有7名，1983年有8名。检测外周血单个核白细胞对IFN-α诱导剂仙台病毒和大肠杆菌以及IFN-γ诱导剂伴刀豆球蛋白A和菜豆凝集素诱导产生IFN的情况。这些诱导剂均无法区分患者和对照。然而，空淋巴细胞中非典型IFN的诱导剂金黄色葡萄球菌考恩I型（SACol），在易感染儿童中诱导产生的IFN明显低于对照组，尤其是伴有关节痛的复发性感染儿童。患者和对照之间在基础NK活性或IFN-α对其体外活性增强方面未发现差异。
