疟疾感染对小鼠中T淋巴细胞依赖性迟发型超敏反应的诱导以及对绵羊红细胞抗体形成的调节作用。
Modulation by malaria infection of the induction of T lymphocyte-dependent delayed-type hypersensitivity and antibody formation to sheep erythrocytes in mice.
作者信息
Michel J C, Lagrange P H, Hurtrel B
出版信息
Parasite Immunol. 1979 Winter;1(4):267-75. doi: 10.1111/j.1365-3024.1979.tb00712.x.
Abstract
A profound alteration of the inductive phase of delayed-type hypersensitivity and antibody formation to SRBC was found in malaria infected mice when sensitization with this antigen was performed intravenously at a critical time of the disease, but not after subcutaneous immunization, suggesting a major role for the spleen in the mechanism of immunodepression.
摘要
当在疾病的关键时期用该抗原进行静脉致敏时，发现疟原虫感染的小鼠对SRBC的迟发型超敏反应和抗体形成的诱导期发生了深刻改变，但皮下免疫后则未出现这种情况，这表明脾脏在免疫抑制机制中起主要作用。
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