Jain Geetika, Chaurasia Radhika, Kaur Bani Preet, Chowdhury Ontar Paul, Roy Hiranmay, Gupta Richa Rani, Biswas Bhaskar, Chakrabarti Sandip, Mukherjee Monalisa
Amity Institute of Nanotechnology, Amity University, Noida, UP 201313, India.
Molecular Science and Engineering Laboratory, Amity Institute of Click Chemistry Research & Studies, Amity University Noida, UP 201313, India.
J Mater Chem B. 2025 Mar 5;13(10):3270-3291. doi: 10.1039/d4tb02682a.
Antibiotic resistance presents an alarming threat to global health, with bacterial infections now ranking among the leading causes of mortality. To address this escalating challenge, strategies such as antibiotic stewardship, development of antimicrobial therapies, and exploration of alternative treatment modalities are imperative. Metal-organic frameworks (MOFs), acclaimed for their outstanding biocompatibility and biodegradability, are promising avenues for the synthesis of novel antibiotic agents under mild conditions. Among these, zeolitic imidazolate frameworks (ZIFs), a remarkable subclass of MOFs, have emerged as potent antibacterial materials; the efficacy of which stems from their porous structure, metal ion content, and tunable functionalized groups. This could be further enhanced by incorporating or encapsulating metal ions, such as Cu, Fe, Ti, Ag, and others. This perspective aims to underscore the potential of ZIFs as antibacterial agents and their underlying mechanisms including the release of metal ions, generation of reactive oxygen species (ROS), disruption of bacterial cell walls, and synergistic interactions with other antibacterial agents. These attributes position ZIFs as promising candidates for advanced applications in combating bacterial infections. Furthermore, we propose a novel approach for synthesizing ZIFs and their derivatives, demonstrating exceptional antibacterial efficacy against and . By highlighting the benefits of ZIFs and their derivatives as antibacterial agents, this perspective emphasizes their potential to address the critical challenge of antibiotic resistance.
抗生素耐药性对全球健康构成了惊人的威胁，细菌感染现已跻身主要死因之列。为应对这一日益严峻的挑战，抗生素管理、抗菌疗法开发以及探索替代治疗方式等策略势在必行。金属有机框架材料（MOFs）因其出色的生物相容性和生物降解性而备受赞誉，是在温和条件下合成新型抗生素的有前景途径。其中，沸石咪唑酯框架材料（ZIFs）作为MOFs的一个显著子类，已成为有效的抗菌材料；其功效源于其多孔结构、金属离子含量和可调节的官能团。通过掺入或封装铜、铁、钛、银等金属离子，这种功效可能会进一步增强。本观点旨在强调ZIFs作为抗菌剂的潜力及其潜在机制，包括金属离子的释放、活性氧（ROS）的产生、细菌细胞壁的破坏以及与其他抗菌剂的协同相互作用。这些特性使ZIFs成为对抗细菌感染的先进应用的有希望候选者。此外，我们提出了一种合成ZIFs及其衍生物的新方法，该方法对[具体细菌1]和[具体细菌2]具有卓越的抗菌效果。通过强调ZIFs及其衍生物作为抗菌剂的益处，本观点强调了它们应对抗生素耐药性这一关键挑战的潜力。
