Wang Si-Rui, Shen Yu-Ting, Huang Bin, Xu Hui-Xiong
Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Ultrasound, Zhejiang Hospital, Hangzhou, China.
Ultrasonography. 2025 Mar;44(2):95-111. doi: 10.14366/usg.24152. Epub 2024 Dec 12.
Radiogenomics, an extension of radiomics, explores the relationship between imaging features and underlying gene expression patterns. This field is instrumental in providing reliable imaging surrogates, thus potentially representing an alternative to genetic testing. The rapidly growing area of radiogenomics that utilizes ultrasound (US) imaging seeks to elucidate the connections between US image characteristics and genomic data. In this review, the authors outline the radiogenomics workflow and summarize the applications of US-based radiogenomics. These include the prediction of gene variations, molecular subtypes, and other biological characteristics, as well as the exploration of the relationships between US phenotypes and cancer gene profiles. Although the field faces various challenges, US-based radiogenomics offers promising prospects and avenues for future research.
放射基因组学作为放射组学的延伸，探索成像特征与潜在基因表达模式之间的关系。该领域有助于提供可靠的成像替代指标，从而有可能成为基因检测的一种替代方法。利用超声（US）成像的放射基因组学这一快速发展的领域旨在阐明US图像特征与基因组数据之间的联系。在这篇综述中，作者概述了放射基因组学的工作流程，并总结了基于US的放射基因组学的应用。这些应用包括基因变异、分子亚型和其他生物学特征的预测，以及US表型与癌症基因谱之间关系的探索。尽管该领域面临各种挑战，但基于US的放射基因组学为未来研究提供了有前景的方向和途径。
