Hakamifard Atousa, Peikar Mohammadsaleh, Tabatabaei Seyed Amirhossein Dormiani
Department of Infectious Diseases, School of Medicine Isfahan University of Medical Sciences Isfahan Iran.
Infectious Diseases and Tropical Medicine Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.
Clin Case Rep. 2025 Feb 10;13(2):e70207. doi: 10.1002/ccr3.70207. eCollection 2025 Feb.
The concurrent occurrence of invasive mold infections caused by two distinct fungal species in hematologic patients represents a rare and challenging condition. The mortality rate associated with these invasive fungal infections in neutropenic patients is high, underscoring the importance of timely diagnosis and prompt initiation of appropriate treatment to improve clinical outcomes. Herein, we present a concomitant acute invasive fungal rhinosinusitis (AIFR) and invasive pulmonary fungal infection caused by and species in a patient with pre-B-cell acute lymphoblastic leukemia. This case highlights the need for further research to optimize outcomes in immunocompromised patients.
血液学患者同时发生由两种不同真菌引起的侵袭性霉菌感染是一种罕见且具有挑战性的情况。中性粒细胞减少患者中这些侵袭性真菌感染的死亡率很高,这凸显了及时诊断和迅速开始适当治疗以改善临床结果的重要性。在此,我们报告一例前B细胞急性淋巴细胞白血病患者同时发生由两种菌种引起的急性侵袭性真菌性鼻窦炎(AIFR)和侵袭性肺部真菌感染。该病例强调了进一步研究以优化免疫受损患者治疗结果的必要性。