两例新冠病毒病并发症急性鼻-鼻窦炎患者合并感染*和*菌属。
Coinfection by and Species in Two Cases of Acute Rhinosinusitis as a Complication of COVID-19.
作者信息
Tabarsi Payam, Sharifynia Somayeh, Pourabdollah Toutkaboni Mihan, Abtahian Zahra, Rahdar Mohammad, Mirahmadian Arefeh Sadat, Hakamifard Atousa
机构信息
Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Case Rep Med. 2022 Mar 14;2022:8114388. doi: 10.1155/2022/8114388. eCollection 2022.
Acute invasive fungal rhinosinusitis (AIFR) is a life-threatening infection often found in immunocompromised patients. In the COVID-19 era, reports of AIFR have emerged, with high mortality and morbidity rate. This paper presents two cases of COVID-19 associated AIFR with the combined proven fungal etiology of and in case 1 and and in case 2. Both patients received liposomal amphotericin B then posaconazole combined with aggressive surgical debridement of necrotic tissues with a favorable clinical outcome. Mixed etiology AIFR can influence the outcome; hence, further studies are required upon this new threat.
急性侵袭性真菌性鼻-鼻窦炎（AIFR）是一种常发生于免疫功能低下患者的危及生命的感染。在新冠疫情时代，已有AIFR的相关报道，其死亡率和发病率都很高。本文介绍了两例与新冠相关的AIFR病例，病例1合并确诊的真菌病原体为 和 ，病例2为 和 。两名患者均接受了脂质体两性霉素B治疗，随后使用泊沙康唑，并积极手术清除坏死组织，临床结果良好。混合病原体所致的AIFR会影响治疗结果；因此，对于这一新威胁需要进一步研究。
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