Aloufi Areej S, Khoumais Nuha, Ahmed Fayka, Hosawi Sara, Sulimani Sameera, Abunayyan Deema, Alghamdi Fadiah, Alshehri Samar, Alsaeed Malak, Sahloul Rasha, Sabir Reem, Harkness Elaine F, Astley Susan M
Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Radiological Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Saudi J Med Med Sci. 2025 Jan-Mar;13(1):7-17. doi: 10.4103/sjmms.sjmms_58_24. Epub 2025 Jan 11.
Breast density is an independent risk factor for breast cancer and affects the sensitivity of mammography screening. Therefore, new breast imaging approaches could benefit women with increased breast density in early cancer detection and diagnosis.
To assess the diagnostic performance of abbreviated breast MRI compared with mammography and other imaging modalities in screening and diagnosing breast cancer among Saudi women with dense breast tissue.
A retrospective diagnostic study was conducted using anonymized medical images and histopathology information from 55 women, aged ≥30 years, who had dense breasts (Breast Imaging and Reporting Data System [BI-RADS] breast density categories C and D) and an abnormal mammogram. The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated for mammography, digital breast tomosynthesis (DBT), synthetic mammography (SM) derived from DBT, ultrasound, and abbreviated breast MRI (ABMRI).
A total of 19 women had pathology-proven breast cancer. Among all methods, ABMRI showed the highest sensitivity (94.7%) and specificity (58.3%), while mammography showed the lowest (84.2% and 44.4%, respectively). AUC for ABMRI was higher than all the methods including mammography (0.751 vs. 0.643; < 0.05).
ABMRI appears to be more accurate in cancer diagnosis than mammography and other modalities for women with dense breast tissue. Further research is advised on a larger sample of Saudi women to confirm the benefit of ABMRI in breast cancer screening and diagnosis for women with increased breast density.
乳腺密度是乳腺癌的一个独立危险因素，并且会影响乳腺钼靶筛查的敏感性。因此，新的乳腺成像方法可能有助于乳腺密度增加的女性进行早期癌症检测和诊断。
评估简化乳腺磁共振成像（ABMRI）与乳腺钼靶及其他成像方式相比，在筛查和诊断乳腺组织致密的沙特女性乳腺癌中的诊断性能。
进行了一项回顾性诊断研究，使用了55名年龄≥30岁、乳腺致密（乳腺影像报告和数据系统[BI-RADS]乳腺密度分类为C和D类）且乳腺钼靶检查异常的女性的匿名医学图像和组织病理学信息。计算了乳腺钼靶、数字乳腺断层合成（DBT）、源自DBT的合成乳腺钼靶（SM）、超声和简化乳腺磁共振成像（ABMRI）的敏感性、特异性和受试者工作特征曲线下面积（AUC）。
共有19名女性患有经病理证实的乳腺癌。在所有方法中，ABMRI显示出最高的敏感性（94.7%）和特异性（58.3%），而乳腺钼靶的敏感性和特异性最低（分别为84.2%和44.4%）。ABMRI的AUC高于包括乳腺钼靶在内的所有方法（0.751对0.643；P<0.05）。
对于乳腺组织致密的女性，ABMRI在癌症诊断中似乎比乳腺钼靶和其他方式更准确。建议对更多沙特女性样本进行进一步研究，以证实ABMRI在乳腺密度增加的女性乳腺癌筛查和诊断中的益处。
