Dillon H C
Rev Infect Dis. 1979 Nov-Dec;1(6):935-45. doi: 10.1093/clinids/1.6.935.
Studies of the epidemiology of acute glomerulonephritis (AGN) following pyoderma reported over the past 15 years have been reviewed. Investigations in Alabama, at Red Lake in Minnesota, and in Trinidad proved of special interest because they contribute new information concerning the natural history of streptococcal skin infections and the role of such infections in AGN. Interesting contrasts between streptococcal infections of the skin and those of the throat are now apparent. Compared with pharyngeal infections, skin infections are more common in young preschool children, are caused by different serotypes, and differ in the nature of the streptococcal antibody response. A number of new M-serotypes of group A streptococci, including several of importance in AGN, were found in studies of pyoderma. In contrast to M-types 1 and 12 (those of major importance in AGN followng pharyngitis), M-types 2, 49, 55, 57, and 60 are now recognized to be of major importance in AGN following pyoderma. Although streptococcal skin infections are quire important in AGN, they do not result in acute rheumatic fever.
对过去15年中报道的脓皮病后急性肾小球肾炎（AGN）流行病学研究进行了综述。阿拉巴马州、明尼苏达州红湖以及特立尼达的调查特别引人关注，因为它们提供了有关链球菌皮肤感染自然史以及此类感染在AGN中作用的新信息。目前，皮肤链球菌感染与咽喉链球菌感染之间存在有趣的差异。与咽部感染相比，皮肤感染在学龄前幼儿中更为常见，由不同血清型引起，并且在链球菌抗体反应的性质上有所不同。在脓皮病研究中发现了一些新的A组链球菌M血清型，其中包括几种在AGN中具有重要意义的血清型。与1型和12型M（在咽炎后AGN中起主要作用的血清型）不同，2型、49型、55型、57型和60型M现在被认为在脓皮病后AGN中起主要作用。虽然链球菌皮肤感染在AGN中相当重要，但它们不会导致急性风湿热。
