灵芝内生木霉菌Trichoderma sp. GLQ02产生的六种新代谢产物及其抗炎活性。
Six new metabolites from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activities.
作者信息
Qiu Xin-Huan, Cheng Xia, Luo Qi, Ma Yun
机构信息
Department of Pharmacy, Clinical Pharmacy Center, Nanfang hospital, Southern Medical University, Guangzhou 510515, China.
Guangzhou Municipal and Guangdong Provincial KeyLaboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
出版信息
Fitoterapia. 2025 Apr;182:106439. doi: 10.1016/j.fitote.2025.106439. Epub 2025 Feb 10.
Six undescribed trichophthalides A-F (1-6) and a known phthalide derivative (7) were isolated from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02. Among them, meroterpenoids 1, 3, 4, 6, and 7 possessed an independent isoprenyl unit with varying degrees of oxidation. The structures and absolute configurations of these substances were elucidated on the basis of spectroscopic data, ECD and DP4+ calculations. Finally, compounds 1, 5, and 7 exhibited relatively weak abilities to inhibit the production of NO in LPS-stimulated RAW 264.7cells at a concentration of 60 μM.
从灵芝来源的内生木霉菌GLQ02中分离出6个未描述的三氯邻苯二甲酸内酯A - F（1 - 6）和1个已知的邻苯二甲酸酯衍生物（7）。其中，杂萜类化合物1、3、4、6和7具有一个独立的异戊烯基单元，且氧化程度不同。基于光谱数据、电子圆二色光谱（ECD）和DP4 +计算确定了这些物质的结构和绝对构型。最后，化合物1、5和7在浓度为60μM时对脂多糖刺激的RAW 264.7细胞中一氧化氮（NO）的产生表现出相对较弱的抑制能力。
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