Zhu Youyang, Tian Miao, Lu Shiyu, Qin Yuliang, Zhao Ting, Shi Hongling, Li Zhaofu, Qin Dongdong
First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China.
The Third Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China.
Brain Res Bull. 2025 Mar;222:111253. doi: 10.1016/j.brainresbull.2025.111253. Epub 2025 Feb 10.
Neurodegenerative diseases (NDDs) are a class of cognitive and motor disorders including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic Lateral Sclerosis (ALS), and others. They are caused by lesions in cells and tissues of the central nervous system, resulting in corresponding dysfunctions and consequent decline in cognitive and motor functions. Neural tissues are extremely vulnerable to oxidative stress, which plays critical biological roles in NDDs. Aromatic compounds are found extensively in natural plants and have substantial effects of anti-oxidative stress damage, which not only have a wide range of research applications in cosmetics, foods, etc., but are also frequently utilized in the treatment of various central nervous system diseases. This review summarizes the relevant oxidative stress mechanisms in NDDs (AD, PD, HD, and ALS) and reviews aromatic compounds such as polyphenols, terpenoids, and flavonoids that can be used in the management of neurodegenerative diseases, as well as their specific mechanisms of antioxidant action. This review will serve as a reference for future experimental studies on neurodegenerative illnesses while also offering fresh insights into clinical therapy.
神经退行性疾病（NDDs）是一类认知和运动障碍，包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿舞蹈病（HD）、肌萎缩侧索硬化症（ALS）等。它们是由中枢神经系统的细胞和组织损伤引起的，导致相应的功能障碍以及随之而来的认知和运动功能衰退。神经组织极易受到氧化应激的影响，氧化应激在神经退行性疾病中起着关键的生物学作用。芳香化合物在天然植物中广泛存在，具有显著的抗氧化应激损伤作用，不仅在化妆品、食品等领域有广泛的研究应用，还经常用于治疗各种中枢神经系统疾病。本综述总结了神经退行性疾病（AD、PD、HD和ALS）中的相关氧化应激机制，并综述了可用于治疗神经退行性疾病的多酚、萜类和黄酮类等芳香化合物及其抗氧化作用的具体机制。本综述将为未来神经退行性疾病的实验研究提供参考，同时也为临床治疗提供新的见解。
