Gataa Ibrahim Saeed, Abdullah Z, González Cabrera María Verónica, S RenukaJyothi, Verma Seema, Arora Isha, Monsi Mekha, Muzammil Khursheed, Zainul Rahadian
Warith Al-Anbiyaa University, Karbala, 56001, Iraq.
Department of Computers Techniques Engineering, College of Technical Engineering, The Islamic University, Najaf, Iraq; Department of Computers Techniques Engineering, College of Technical Engineering, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
Nutr Metab Cardiovasc Dis. 2025 Jun;35(6):103858. doi: 10.1016/j.numecd.2025.103858. Epub 2025 Jan 6.
This research delved into a comprehensive examination and detailed analysis of the effects of whey protein (WP) supplementation on lipid profile in adults.
Data used in this research was obtained from diverse clinical trials. Thorough searches were carried out on multiple electronic platforms including PubMed, Embase, Web of Science, Scopus, Google Scholar, and the Cochrane Library from their inception until May 2024. Random effects models were assessed and pooled data were determined as weighted mean differences (WMDs) with a 95 % confidence interval (CI).
Overall, 20 randomized clinical trials (n = 1638 participants) met our inclusion criteria. The current meta-analysis demonstrates a significant reduction in TG (WMD: -12.21 mg/dL; %95CI: -20.16, -4.26; P = 0.003). Pooled analysis of 19 studies on HDL-c indicated a significant increase (WMD: 2.59 mg/dL; %95CI: 1.11, 4.07; P = 0.001).
We found that WP intake can improve TG and HDL-c significantly without significant effects on TC, and LDL-c levels. However, future well-designed with long duration RCTs is required on diverse populations to understand better the effects of these natural compounds and their constituents on lipid profile in adults.
本研究深入全面地考察并详细分析了补充乳清蛋白（WP）对成年人血脂水平的影响。
本研究中使用的数据来自各种临床试验。从多个电子平台（包括PubMed、Embase、科学网、Scopus、谷歌学术和考克兰图书馆）自创建起至2024年5月进行了全面检索。评估了随机效应模型，并将汇总数据确定为加权平均差（WMD），置信区间为95%（CI）。
总体而言，20项随机临床试验（n = 1638名参与者）符合我们的纳入标准。当前的荟萃分析表明甘油三酯显著降低（WMD：-12.21mg/dL；95%CI：-20.16，-4.26；P = 0.003）。对19项关于高密度脂蛋白胆固醇（HDL-c）的研究进行的汇总分析表明显著升高（WMD：2.59mg/dL；95%CI：1.11，4.07；P = 0.001）。
我们发现摄入WP可显著改善甘油三酯和HDL-c水平，而对总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-c）水平无显著影响。然而，未来需要针对不同人群开展设计良好、持续时间长的随机对照试验，以更好地了解这些天然化合物及其成分对成年人血脂水平的影响。
