Rodriguez-Torres Juan Francisco, Romero-Ibarguengoitia Maria Elena, Garza-Silva Arnulfo, Rivera-Cavazos Andrea, Hurtado-Cabrera Mauricio, Kalife-Assad Ricardo, Villarreal-Parra Diana Liz, Loose-Esparza Alejandro, Gutierrez-Arias Juan José, Mata-Porras Yaressi Guadalupe, Ojeda-Salazar Daniela Abigail, Morales-Rodriguez Devany Paola, Sanz-Sánchez Miguel Ángel, Gonzalez-Cantú Arnulfo
Internal Medicine Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo León, Mexico.
Vicerrectoría de Ciencias de la Salud, Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Nuevo León, Mexico.
Sci Rep. 2025 Feb 12;15(1):5301. doi: 10.1038/s41598-024-59954-z.
The COVID-19 pandemic had a profound global impact, characterized by a high fatality rate and the emergence of enduring consequences known as Long COVID. Our study sought to gauge the prevalence of Long COVID syndrome in northeastern Mexico, correlating it with patients' comorbidities and vaccination records. We carried out an observational cross-sectional approach, by administering a comprehensive questionnaire covering patients' medical history, demographics, vaccination status, COVID-related symptoms, their duration, and any treatment received. Our participant cohort included 804 patients, averaging 41.5 (SD 13.6) years in age, with 59.3% being women. Notably, 168 individuals (20.9%) met Long COVID criteria. Our analysis of COVID-19 long lasting compared vaccination schemes, unveiling a significant difference between vaccinated and unvaccinated groups (p = < 0.001). Through linear regression model, we found male gender (β = - 0.588, p < 0.001) and vaccination status (β = 0.221, p = 0.015) acted as protective factors against Long COVID symptom duration, while higher BMI was a risk factor (β = - 0.131, p = 0.026). We saw that the duration of Long COVID was different within vaccinated patients, and we did not find any association of comorbidities with an increase in the presence of symptoms. Even three years after the pandemic, a significant prevalence of Long COVID persists, and there is still a lack of standardized information and any possible treatment regarding this condition.
新冠疫情对全球产生了深远影响，其特点是死亡率高，并出现了被称为“长新冠”的长期后果。我们的研究旨在评估墨西哥东北部“长新冠”综合征的患病率，并将其与患者的合并症和疫苗接种记录相关联。我们采用观察性横断面研究方法，通过发放一份涵盖患者病史、人口统计学、疫苗接种状况、新冠相关症状、症状持续时间以及所接受任何治疗的综合问卷来进行研究。我们的参与者队列包括804名患者，平均年龄为41.5岁（标准差13.6），其中59.3%为女性。值得注意的是，168人（20.9%）符合“长新冠”标准。我们对新冠长期影响与疫苗接种方案进行分析，发现接种疫苗组和未接种疫苗组之间存在显著差异（p = <0.001）。通过线性回归模型，我们发现男性（β = -0.588，p < 0.001）和疫苗接种状况（β = 0.221，p = 0.015）是“长新冠”症状持续时间的保护因素，而较高的体重指数是一个风险因素（β = -0.131，p = 0.026）。我们发现接种疫苗的患者中“长新冠”的持续时间有所不同，并且我们没有发现合并症与症状出现增加之间存在任何关联。即使在疫情爆发三年后，“长新冠”的患病率仍然很高，而且对于这种情况仍然缺乏标准化信息和任何可能的治疗方法。
