厚壁刚性和薄壁柔性多壁碳纳米管在肺部致癌潜力的综述
A Review of the Carcinogenic Potential of Thick Rigid and Thin Flexible Multi-Walled Carbon Nanotubes in the Lung.
作者信息
Ahmed Omnia Hosny Mohamed, Naiki-Ito Aya, Takahashi Satoru, Alexander William T, Alexander David B, Tsuda Hiroyuki
机构信息
Nanotoxicology Project, Nagoya City University, Nagoya 467-8603, Japan.
Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
出版信息
Nanomaterials (Basel). 2025 Jan 22;15(3):168. doi: 10.3390/nano15030168.
The carcinogenic potential of MWCNTs is not well defined. Currently, IARC has classified MWCNT-7 as a Group 2 B material, possibly carcinogenic to humans, and all other MWCNTs as Group 3 materials, inadequate evidence in experimental animals for their carcinogenicity and not classifiable as to their carcinogenicity to humans. In this review we discuss studies that investigated the lung toxicity of well characterized MWCNTs in mice and rats. Intraperitoneal and intrascrotal injection studies identified rigid MWCNTs as hazardous materials. The assessment of lung toxicity of MWCNTs in short and medium term instillation and inhalation studies were not conclusive; therefore, these studies do not confirm the hazard of MWCNTs. However, two-year carcinogenicity studies indicate that MWCNT-7 and other MWCNTs, both thick rigid MWCNTs and thin flexible MWCNTs, are carcinogenic in test animals. Therefore, the carcinogenicity of MWCNTs in experimental animals should be reassessed.
多壁碳纳米管的致癌潜力尚未明确界定。目前，国际癌症研究机构已将多壁碳纳米管-7归类为2B组物质，可能对人类致癌，而所有其他多壁碳纳米管归类为3组物质，实验动物中缺乏其致癌性的充分证据，且无法对其对人类的致癌性进行分类。在本综述中，我们讨论了研究明确特征的多壁碳纳米管在小鼠和大鼠肺部毒性的研究。腹腔内和阴囊内注射研究确定刚性多壁碳纳米管为有害物质。多壁碳纳米管在短期和中期滴注及吸入研究中的肺部毒性评估尚无定论；因此，这些研究未证实多壁碳纳米管的危害。然而，两年致癌性研究表明，多壁碳纳米管-7和其他多壁碳纳米管，包括厚刚性多壁碳纳米管和薄柔性多壁碳纳米管，在实验动物中具有致癌性。因此，应重新评估多壁碳纳米管在实验动物中的致癌性。
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