Kellogg Julianne A, Monsivais Pablo, Murphy Kevin M, Perrigue Martine M
Department of Crop and Soil Sciences, College of Agricultural, Human, and Natural Resource Sciences, Washington State University, Pullman, WA 99164, USA.
Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
Nutrients. 2025 Jan 24;17(3):430. doi: 10.3390/nu17030430.
BACKGROUND/OBJECTIVES: The effects of sweetened and unsweetened high β-glucan whole grain barley on postprandial blood glucose response in normoglycemic human subjects were evaluated in a randomized, controlled, crossover clinical trial.
Sixteen healthy, over-night fasted participants were studied on four or eight separate occasions. Participants consumed an unsweetened preload condition ( = 16): white glutinous rice (WR; 0 g β-glucan), low β-glucan barley (LB; ~4 g), medium β-glucan barley (MB; ~5 g), or high β-glucan barley (HB; ~6 g); or a sweetened condition with high fructose corn syrup (HFCS; = 8): WR + 50 g HFCS, LB + 50 g HFCS, MB + 50 g HFCS, or HB + 50 g HFCS. After consuming the preload as a breakfast food, participants self-administered blood glucose tests every 15 min for four hours.
In both sweetened and unsweetened conditions, higher β-glucan content was associated with lower blood glucose peak response and incremental area under the curve estimates (iAUC). In comparison to the unsweetened conditions, the sweetened conditions resulted in less prominent decreases in mean blood glucose response and iAUC blood glucose as β-glucan content increased.
By attenuating postprandial glycemic response, high β-glucan whole grain barley foods could play a role in helping to control blood glucose.
背景/目的：在一项随机、对照、交叉临床试验中，评估了添加甜味剂和未添加甜味剂的高β-葡聚糖全谷物大麦对血糖正常的人类受试者餐后血糖反应的影响。
对16名健康的过夜禁食参与者进行了4次或8次单独研究。参与者在未添加甜味剂的情况下（n = 16）食用：白糯米（WR；0克β-葡聚糖）、低β-葡聚糖大麦（LB；约4克）、中β-葡聚糖大麦（MB；约5克）或高β-葡聚糖大麦（HB；约6克）；或在添加高果糖玉米糖浆的情况下（n = 8）食用：WR + 50克高果糖玉米糖浆、LB + 50克高果糖玉米糖浆、MB + 50克高果糖玉米糖浆或HB + 50克高果糖玉米糖浆。将预负荷食物作为早餐食用后，参与者在4小时内每隔15分钟自行进行一次血糖测试。
在添加甜味剂和未添加甜味剂的两种情况下，较高的β-葡聚糖含量均与较低的血糖峰值反应和曲线下增量面积估计值（iAUC）相关。与未添加甜味剂的情况相比，随着β-葡聚糖含量增加，添加甜味剂的情况下平均血糖反应和血糖iAUC的下降不太明显。
通过减弱餐后血糖反应，高β-葡聚糖全谷物大麦食品可能有助于控制血糖。
