Ratajczak-Pawłowska Alicja Ewa, Michalak Michał, Szymczak-Tomczak Aleksandra, Rychter Anna Maria, Zawada Agnieszka, Skoracka Kinga, Dobrowolska Agnieszka, Krela-Kaźmierczak Iwona
Laboratory of Nutrigenetics, Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Nutrients. 2025 Jan 28;17(3):466. doi: 10.3390/nu17030466.
: The study aimed to investigate the association between fat body mass and bone mineral density (BMD) of the lumbar spine (L1-L4), femoral neck, and total body. : We studied 95 patients with Crohn's disease (CD), 68 with ulcerative colitis (UC), and 40 healthy adults (control group-CG) aged 18-50 years old. The BMD of lumbar spine and femoral neck was assessed as well as body composition. : A lower fat mass percentage was observed in about 8% of CD, 13% of UC, and 3% of CG. An increased percentage of fat mass was common, and occurred above 50% of CD, 40% of UC, and about 60% of CG. Body fat mass and fat mass percentage were significantly lower among UC compared with the CG (-value < 0.001) and CD (-value < 0.01) in women. Body fat mass correlated positively with the BMD and T-score of L1-L4 and total body mass in men with UC. We found a positive correlation between the fat body mass and BMD and T-score of L1-L4, femoral neck, and total body in women with IBD. Among CG, positive correlations occurred between the fat body mass and BMD of L1-L4, BMD of total body, and T-score of total body, but only in men. CRP (C-reactive protein) correlated negatively with fat body mass only in men with CD. : A higher fat mass percentage is common among IBD patients and healthy adults despite a normal body mass index. Body fat mass is a predictor of nutritional status and likely influences the course of the disease, as it correlated positively with BMD, T-score, and Z-score. The association between fat tissue and bone health appears to be stronger in women. Further studies are needed to investigate additional factors that may affect bone health in IBD.
该研究旨在调查脂肪量与腰椎（L1-L4）、股骨颈及全身骨密度（BMD）之间的关联。我们研究了95例克罗恩病（CD）患者、68例溃疡性结肠炎（UC）患者以及40名年龄在18至50岁的健康成年人（对照组-CG）。评估了腰椎和股骨颈的骨密度以及身体成分。约8%的CD患者、13%的UC患者和3%的CG人群脂肪量百分比降低。脂肪量百分比增加较为常见，在超过50%的CD患者、40%的UC患者和约60%的CG人群中出现。在女性中，UC患者的身体脂肪量和脂肪量百分比显著低于CG（P值<0.001）和CD（P值<0.01）。在患有UC的男性中，身体脂肪量与L1-L4及全身的骨密度和T值呈正相关。我们发现患有炎症性肠病（IBD）的女性中，脂肪量与L1-L4、股骨颈及全身的骨密度和T值呈正相关。在CG人群中，仅在男性中脂肪量与L1-L4的骨密度、全身骨密度及全身T值呈正相关。仅在患有CD的男性中，C反应蛋白（CRP）与脂肪量呈负相关。尽管体重指数正常，但IBD患者和健康成年人中较高的脂肪量百分比较为常见。身体脂肪量是营养状况的一个预测指标，并且可能影响疾病进程，因为它与骨密度、T值和Z值呈正相关。脂肪组织与骨骼健康之间的关联在女性中似乎更强。需要进一步研究以调查可能影响IBD患者骨骼健康的其他因素。
Zotero 插件