Sikovanyecz János, Gullo Giuseppe, Vincze Márió, Földesi Imre, Németh Gábor, Surányi Andrea, Sikovanyecz János, Kozinszky Zoltan
Department of Obstetrics and Gynecology, University of Szeged, 6725 Szeged, Hungary.
IVF Unit, Department of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, University of Palermo, 90146 Palermo, Italy.
Diagnostics (Basel). 2025 Jan 29;15(3):317. doi: 10.3390/diagnostics15030317.
Laeverin is an extravillous trophoblast marker playing a significant role in trophoblast migration. We endeavored to estimate the association between the amniotic and serum laeverin concentrations at 16-22 weeks of gestation and the fetal and placental ultrasound measurements in high-risk uncomplicated pregnancies. A prospective cross-sectional study of consecutively recruited singleton pregnancies undergoing amniocentesis was performed. Fetal structural malformations and/or aneuploidy were the exclusion criteria. Fetal biometric parameters and placental growth/perfusion were assessed by ultrasound in 44 high-risk pregnancies who had no pregnancy complications and any other chronic disease. Maternal serum and amniotic laeverin levels were essayed with sandwich enzyme-linked immunosorbent assay. Serum laeverin levels are decreasing marginally with the maternal age in mid-gestation. Laeverin levels in the serum correlated minimally negatively with head size of the fetus (β = -0.38; < 0.05; 95% confidence interval (CI) -0.03-0.01), whereas the amniotic level correlated strongly with the fetal abdominal circumference (β = -0.74; < 0.05; 95% CI: -0.34--0.09). In addition, the amniotic laeverin level correlated moderately and positively with the placental volume (β = 0.46; < 0.05; 95% CI: 0.01-0.08). Laeverin levels detected in the serum and in the amniotic fluid denote the fetoplacental growth in uncomplicated high-risk pregnancies.
拉维林是一种绒毛外滋养层标志物，在滋养层迁移中起重要作用。我们试图评估妊娠16 - 22周时羊水中和血清中拉维林浓度与高危无并发症妊娠中胎儿及胎盘超声测量值之间的关联。对连续招募的接受羊膜穿刺术的单胎妊娠进行了一项前瞻性横断面研究。胎儿结构畸形和/或非整倍体为排除标准。通过超声评估了44例无妊娠并发症及任何其他慢性病的高危妊娠的胎儿生物测量参数和胎盘生长/灌注情况。采用夹心酶联免疫吸附测定法检测孕妇血清和羊水中的拉维林水平。妊娠中期血清拉维林水平随孕妇年龄略有下降。血清中拉维林水平与胎儿头围呈最小程度的负相关(β = -0.38;P<0.05;95%置信区间(CI) -0.03 - 0.01)，而羊水中的拉维林水平与胎儿腹围呈强相关(β = -0.74;P<0.05;95% CI: -0.34 - -0.09)。此外，羊水中的拉维林水平与胎盘体积呈中度正相关(β = 0.46;P<0.05;95% CI: 0.01 - 0.08)。血清和羊水中检测到的拉维林水平表明无并发症高危妊娠中的胎儿-胎盘生长情况。
