Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
J Am Geriatr Soc. 2014 Apr;62(4):667-72. doi: 10.1111/jgs.12740. Epub 2014 Mar 17.
To assess the associations among age, health status, and resting metabolic rate (RMR) in a large population of older adults.
Cross-sectional analysis.
Community-dwelling volunteers from the Baltimore Longitudinal Study of Aging (BLSA).
Persons aged 40 to 96 (mean 68.2 ± 11.0) who underwent a comprehensive physical examination, cognitive assessment, RMR testing, body composition assessment, and physical function testing during a 3-day clinic visit (N = 420).
Participants were assigned to Insight into the Determination of Exceptional Aging and Longevity (IDEAL) or non-IDEAL categories based on health status. IDEAL participants were defined according to the absence of physical and cognitive impairments, chronic conditions and comorbidities, and blood profile abnormalities. A three-stage linear regression model was used to assess the relationship between RMR and age, using IDEAL classification as a predictor and adjusting for sex and body composition.
Resting metabolic rate averaged 1,512.4 ± 442.9 kcal/d and was lower with older age (β = -8.55, P < .001). After adjusting for age, sex, and body composition, RMR was 109.6 kcal/d lower in IDEAL than non-IDEAL participants (P < .005).
Individuals who are fully functional and free of major medical conditions have lower RMR than those with disease and functional impairments. These findings suggest that health status plays a role in energy use and regulation independent of age and body composition and that elevated RMR may be a global biomarker of poor health in older persons.
在大量老年人中评估年龄、健康状况和静息代谢率（RMR）之间的关系。
横断面分析。
巴尔的摩老龄化纵向研究（BLSA）的社区居住志愿者。
年龄在 40 至 96 岁之间（平均 68.2 ± 11.0）的人，他们在为期 3 天的诊所就诊期间接受了全面的体检、认知评估、RMR 测试、身体成分评估和身体功能测试（N = 420）。
根据健康状况，参与者被分配到洞察决定卓越衰老和长寿（IDEAL）或非 IDEAL 类别。IDEAL 参与者根据无身体和认知障碍、慢性疾病和合并症以及血液谱异常定义。使用三阶段线性回归模型评估 RMR 与年龄之间的关系，使用 IDEAL 分类作为预测因素，并调整性别和身体成分。
静息代谢率平均为 1512.4 ± 442.9 kcal/d，随年龄增长而降低（β = -8.55，P <.001）。在调整年龄、性别和身体成分后，IDEAL 参与者的 RMR 比非 IDEAL 参与者低 109.6 kcal/d（P <.005）。
功能完全且无重大医疗条件的个体的 RMR 低于有疾病和功能障碍的个体。这些发现表明，健康状况在独立于年龄和身体成分的情况下对能量使用和调节起作用，并且升高的 RMR 可能是老年人健康状况不佳的全球生物标志物。
