Bezerra Daniella Teixeira, Mesquita-Ferrari Raquel Agnelli, Fernandes Kristianne Porta Santos, Bussadori Sandra Kalil, Motta Lara Jansiski, Ando-Suguimoto Ellen Sayuri, Frochot Céline, Perini Alessandra Messina, Rossi Flavia, Mimica Marcelo Jenne, Pereira Benedito Jorge, Horliana Anna Carolina Ratto Tempestini
Postgraduate Program in Biophotonics-Medicine, University Nove de Julho, UNINOVE, São Paulo 01504-001, Brazil.
Postgraduate Program in Rehabilitation Sciences, University Nove de Julho, UNINOVE, São Paulo 01504-001, Brazil.
Healthcare (Basel). 2025 Jan 26;13(3):245. doi: 10.3390/healthcare13030245.
Infection poses a significant threat of mortality in patients with chronic kidney disease (CKD) undergoing hemodialysis. () is a common etiological agent, with prior nasal colonization identified as a risk factor for infection. The aim of the present cross-sectional study was to determine the prevalence of nasal carriage among patients with CKD undergoing dialysis at a university hospital and identify potential factors associated with colonization. Nasal swabs were obtained, and bacterial isolates were identified using matrix-assisted laser desorption/ionization time-of-flight spectrometry and antibiogram testing with the Vitek 2 system. Demographic and clinical data were collected for the investigation of risk factors associated with colonization. Among the 96 patients analyzed, 34 were carriers of Among these carriers, three (8.8%) harbored oxacillin-resistant strains. More than half of the strains exhibited resistance to clindamycin but susceptibility to oxacillin. Colonization was associated with age and the use of corticosteroids/immunosuppressants. The prevalence of nasal carriage was high among patients undergoing dialysis at the university hospital, exceeding that found in the general population. Nasal colonization by was linked to corticosteroid use and age. Understanding factors associated with nasal colonization in patients on dialysis can assist healthcare providers in preventing the spread of infection and cross-contamination, while reducing risk in this population.
感染对接受血液透析的慢性肾脏病（CKD）患者构成了重大的死亡威胁。（）是一种常见的病原体，先前的鼻腔定植被确定为感染的危险因素。本横断面研究的目的是确定某大学医院接受透析的CKD患者中鼻腔携带（病原体）的患病率，并确定与定植相关的潜在因素。采集了鼻拭子，并使用基质辅助激光解吸/电离飞行时间光谱法和Vitek 2系统进行抗菌谱测试来鉴定细菌分离株。收集了人口统计学和临床数据以调查与定植相关的危险因素。在分析的96例患者中，34例为（病原体）携带者。在这些携带者中，三例（8.8%）携带耐苯唑西林菌株。超过一半的（病原体）菌株对克林霉素耐药，但对苯唑西林敏感。定植与年龄以及皮质类固醇/免疫抑制剂的使用有关。该大学医院接受透析的患者中鼻腔携带（病原体）的患病率很高，超过了普通人群中的患病率。（病原体）的鼻腔定植与皮质类固醇的使用和年龄有关。了解透析患者鼻腔定植（病原体）的相关因素有助于医护人员预防感染传播和交叉污染，同时降低该人群的风险。
