Naccari Clara, Ginestra Giovanna, Micale Nicola, Palma Ernesto, Galletta Benedetta, Costa Rosaria, Vadalà Rossella, Nostro Antonia, Cristani Mariateresa
Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.
Molecules. 2025 Jan 21;30(3):438. doi: 10.3390/molecules30030438.
: The lack of new antimicrobial drugs and increased antimicrobial resistance has focused attention on the employment of essential oils (EOs) in human and veterinary medicine. The aim of this study was to test new binary associations between known and uncommon EOs. : EOs from L., L., L., L. var. were tested individually and in binary combinations to study, as follows: antibacterial activity against , including methicillin-resistant (MRSA) and ; antioxidant capacity via redox-based assays (DPPH, ABTS and FRAP); and anti-inflammatory activity via the bovine serum albumin denaturation inhibition assay. L. showed good antibacterial activity against all strains (MIC = 0.03-0.12%, /), followed by L., and also had the best antioxidant and anti-inflammatory activities. Synergistic and additive effects were observed for the EO combinations L./ L. and L./ L. against and MRSA, respectively. A reduction in biofilm was noted. Antioxidant and anti-inflammatory activities were also detected. : The results suggest that EO combinations may be a promising strategy in veterinary settings for the treatment of infectious diseases caused by , including drug-resistant and biofilm-forming strains accompanied by oxidative stress and inflammation.
新型抗菌药物的匮乏以及抗菌耐药性的增加，使得人们将注意力集中在精油在人类医学和兽医学中的应用上。本研究的目的是测试已知和不常见精油之间新的二元组合。对来自[植物名称1]、[植物名称2]、[植物名称3]、[植物名称4]变种的精油进行了单独测试和二元组合测试，研究内容如下：对金黄色葡萄球菌（包括耐甲氧西林金黄色葡萄球菌（MRSA））和[其他菌株名称]的抗菌活性；通过基于氧化还原的分析方法（DPPH、ABTS和FRAP）测定抗氧化能力；以及通过牛血清白蛋白变性抑制试验测定抗炎活性。[植物名称1]对所有菌株均表现出良好的抗菌活性（MIC = 0.03 - 0.12%，[单位1]/[单位2]），其次是[植物名称2]，并且还具有最佳的抗氧化和抗炎活性。分别观察到[植物名称1]/[植物名称2]和[植物名称1]/[植物名称3]精油组合对[菌株名称]和MRSA的协同和相加作用。生物膜有所减少。还检测到了抗氧化和抗炎活性。结果表明，在兽医领域，精油组合可能是治疗由[菌株名称]引起的传染病的一种有前景的策略，这些传染病包括耐药和形成生物膜的菌株，并伴有氧化应激和炎症。
